Cholecystokinin B receptor

CCKBR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L4T
Identifiers
Aliases	CCKBR, CCK-B, CCK2R, GASR, cholecystokinin B receptor
External IDs	OMIM: 118445 MGI: 99479 HomoloGene: 7258 GeneCards: CCKBR
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,272,127 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,120,105 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; body of stomach; ; dorsolateral prefrontal cortex; ; cingulate gyrus; ; middle temporal gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; Brodmann area 9; ; cerebellar vermis;
	Top expressed in
	primary motor cortex; ; piriform cortex; ; prefrontal cortex; ; entorhinal cortex; ; superior frontal gyrus; ; inferior colliculus; ; ventromedial nucleus; ; motor neuron; ; olfactory bulb; ; medulla oblongata;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; 1-phosphatidylinositol-3-kinase regulator activity; protein binding; type B gastrin/cholecystokinin receptor binding; gastrin receptor activity; cholecystokinin receptor activity; peptide hormone binding;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	gastric acid secretion; positive regulation of cytosolic calcium ion concentration; cell surface receptor signaling pathway; positive regulation of cell population proliferation; cell population proliferation; digestive tract development; signal transduction; gland development; regulation of phosphatidylinositol 3-kinase activity; G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; cholecystokinin signaling pathway; pH reduction;
	Sources:Amigo / QuickGO
Orthologs
	887
	12426
	ENSG00000110148
	ENSMUSG00000030898
	P32239
	P56481
	NM_176875; NM_001318029; NM_001363552
	NM_007627
	NP_001304958; NP_795344; NP_001350481
	NP_031653
	Wikidata
View/Edit Human	View/Edit Mouse

The cholecystokinin B receptor also known as CCKBR or CCK₂ is a protein that in humans is encoded by the CCKBR gene.

This gene encodes a G protein-coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.

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