Chlorambucil

Chlorambucil
Clinical data
Trade names	Leukeran, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682899
Routes of; administration	By mouth
ATC code	L01AA02 (WHO) ;
Legal status
Legal status	US: WARNING; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	?
Metabolism	Liver
Elimination half-life	1.5 hours
Excretion	N/A
Identifiers
	IUPAC name 4-[bis(2-chlorethyl)amino]benzenebutanoic acid;
CAS Number	305-03-3 ;
PubChem CID	2708;
IUPHAR/BPS	7143;
DrugBank	DB00291 ;
ChemSpider	2607 ;
UNII	18D0SL7309;
KEGG	D00266 ;
ChEBI	CHEBI:28830 ;
ChEMBL	ChEMBL515 ;
CompTox Dashboard (EPA)	DTXSID7020263 ;
ECHA InfoCard	100.005.603
Chemical and physical data
Formula	C14H19Cl2NO2
Molar mass	304.21 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClCCN(CCCl)c1ccc(cc1)CCCC(=O)O;
	InChI InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19) ; Key:JCKYGMPEJWAADB-UHFFFAOYSA-N ;
	(verify)

Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. For CLL it is a preferred treatment. It is given by mouth.

Common side effects include bone marrow suppression. Other serious side effects include an increased long term risk of further cancer, infertility, and allergic reactions. Use during pregnancy often results in harm to the baby. Chlorambucil is in the alkylating agent family of medications. It works by blocking the formation of DNA and RNA.

Chlorambucil was approved for medical use in the United States in 1957. It is on the World Health Organization's List of Essential Medicines. It was originally made from nitrogen mustard.

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