Chain termination

In polymer chemistry, chain termination is any chemical reaction that ceases the formation of reactive intermediates in a chain propagation step in the course of a polymerization, effectively bringing it to a halt.

IUPAC definition

Chemical reaction in which a chain carrier is converted irreversibly into
a non-propagating species without the formation of a new chain carrier.

For the DNA sequencing method, see Sanger sequencing and nucleoside analogue.
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