DNA replication factor CDT1

CDT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LE8, 2WVR
Identifiers
Aliases	CDT1, DUP, RIS2, chromatin licensing and DNA replication factor 1
External IDs	OMIM: 605525 MGI: 1914427 HomoloGene: 32650 GeneCards: CDT1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	88,809,258 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,300,293 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ganglionic eminence; ; spongy bone; ; bone marrow; ; stromal cell of endometrium; ; amniotic fluid; ; placenta; ; bone marrow cells; ; skin of abdomen;
	Top expressed in
	endocardial cushion; ; abdominal wall; ; primitive streak; ; condyle; ; fossa; ; Paneth cell; ; vas deferens; ; ureter; ; medial ganglionic eminence; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; chromatin binding; DNA polymerase binding;
Cellular component	cytosol; nucleus; nucleoplasm; nuclear body; chromosome, centromeric region; chromosome; kinetochore; cytoplasm;
Biological process	DNA replication checkpoint signaling; DNA replication; cell cycle; regulation of nuclear cell cycle DNA replication; regulation of transcription involved in G1/S transition of mitotic cell cycle; regulation of DNA-dependent DNA replication initiation; chromosome segregation; attachment of mitotic spindle microtubules to kinetochore; mitotic cell cycle; positive regulation of protein-containing complex assembly; regulation of chromosome organization; positive regulation of chromatin binding; cell division; kinetochore organization; DNA replication preinitiation complex assembly; response to sorbitol; deactivation of mitotic spindle assembly checkpoint; regulation of DNA replication origin binding; negative regulation of protein localization to kinetochore; positive regulation of protein localization to kinetochore; positive regulation of DNA-dependent DNA replication; positive regulation of mediator complex assembly; G1/S transition of mitotic cell cycle; positive regulation of DNA replication; mitotic cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	81620
	67177
	ENSG00000167513
	ENSMUSG00000006585
	Q9H211
	Q8R4E9
	NM_030928
	NM_026014
	NP_112190
	NP_080290
	Wikidata
View/Edit Human	View/Edit Mouse

CDT1 (Chromatin licensing and DNA replication factor 1) is a protein that in humans is encoded by the CDT1 gene. It is a licensing factor that functions to limit DNA from replicating more than once per cell cycle.

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