CDC20

CDC20
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GGA, 4GGC, 4GGD, 4N14, 5G04
Identifiers
Aliases	CDC20, CDC20A, bA276H19.3, p55CDC, cell division cycle 20
External IDs	OMIM: 603618 MGI: 1859866 HomoloGene: 37459 GeneCards: CDC20
Gene location (Human)
Chr.	Chromosome 1 (human)
End	43,363,203 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	118,294,549 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; embryo; ; ganglionic eminence; ; spongy bone; ; thymus; ; stromal cell of endometrium; ; bone marrow; ; appendix; ; rectum;
	Top expressed in
	medial ganglionic eminence; ; primitive streak; ; abdominal wall; ; ureter; ; endocardial cushion; ; internal carotid artery; ; renal corpuscle; ; external carotid artery; ; hair follicle; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein C-terminus binding; protein binding; anaphase-promoting complex binding; ubiquitin-protein transferase activator activity; enzyme binding; histone deacetylase binding;
Cellular component	centrosome; spindle pole; spindle; microtubule organizing center; perinuclear region of cytoplasm; anaphase-promoting complex; cytoskeleton; cytoplasm; nucleus; nucleoplasm; cytosol; protein-containing complex;
Biological process	cell differentiation; regulation of meiotic nuclear division; regulation of dendrite development; nervous system development; positive regulation of synaptic plasticity; cell division; positive regulation of synapse maturation; protein ubiquitination; positive regulation of cell population proliferation; anaphase-promoting complex-dependent catabolic process; positive regulation of ubiquitin protein ligase activity; mitotic sister chromatid cohesion; protein deubiquitination; mitotic spindle assembly; cell cycle; mitotic spindle assembly checkpoint signaling; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	991
	107995
	ENSG00000117399
	ENSMUSG00000006398
	Q12834
	Q9JJ66
	NM_001255
	NM_023223
	NP_001246
	NP_075712
	Wikidata
View/Edit Human	View/Edit Mouse

The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/C^Cdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.

CDC20 appears to act as a regulatory protein interacting with many other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes: nuclear movement prior to anaphase, and chromosome separation.

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