Glycoprotein 130

IL6ST
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BJ8, 1BQU, 1I1R, 1P9M, 1PVH, 3L5H, 3L5I, 3L5J,%%s1BJ8, 1BQU, 1I1R, 1P9M, 1PVH, 3L5H, 3L5I, 3L5J, 1N2Q
Identifiers
Aliases	IL6ST, CD130, CDW130, GP130, IL-6RB, interleukin 6 signal transducer
External IDs	OMIM: 600694 MGI: 96560 HomoloGene: 1645 GeneCards: IL6ST
Gene location (Human)
Chr.	Chromosome 5 (human)
End	55,994,993 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	112,646,620 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; germinal epithelium; ; visceral pleura; ; seminal vesicula; ; caput epididymis; ; superficial temporal artery; ; pericardium; ; lactiferous duct; ; lower lobe of lung; ; urethra;
	Top expressed in
	uterus; ; right lung; ; right lung lobe; ; carotid body; ; urinary bladder; ; ankle; ; aortic valve; ; belly cord; ; sciatic nerve; ; aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	interleukin-11 binding; leukemia inhibitory factor receptor activity; ciliary neurotrophic factor receptor binding; interleukin-27 receptor activity; ciliary neurotrophic factor receptor activity; cytokine receptor activity; protein homodimerization activity; interleukin-6 receptor binding; growth factor binding; interleukin-11 receptor activity; oncostatin-M receptor activity; interleukin-6 receptor activity; interleukin-6 binding; protein binding; cytokine binding; identical protein binding;
Cellular component	extracellular exosome; extracellular region; integral component of membrane; cell body; ciliary neurotrophic factor receptor complex; membrane; neuronal cell body; dendrite; plasma membrane; interleukin-6 receptor complex; oncostatin-M receptor complex; external side of plasma membrane; extracellular space; receptor complex;
Biological process	regulation of Notch signaling pathway; positive regulation of cardiac muscle hypertrophy; negative regulation of apoptotic process; negative regulation of interleukin-6-mediated signaling pathway; interleukin-11-mediated signaling pathway; response to cytokine; oncostatin-M-mediated signaling pathway; signal transduction; interleukin-27-mediated signaling pathway; positive regulation of adaptive immune response; ciliary neurotrophic factor-mediated signaling pathway; leukemia inhibitory factor signaling pathway; viral process; positive regulation of T cell proliferation; interleukin-6-mediated signaling pathway; positive regulation of acute inflammatory response; cytokine-mediated signaling pathway; positive regulation of astrocyte differentiation; positive regulation of osteoblast differentiation; glycogen metabolic process; positive regulation of vascular endothelial growth factor production; positive regulation of cell population proliferation; positive regulation of tyrosine phosphorylation of STAT protein; interleukin-12-mediated signaling pathway; interleukin-35-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3572
	16195
	ENSG00000134352
	ENSMUSG00000021756
	P40189; Q17RA0
	Q00560
	NM_001190981; NM_002184; NM_175767
	NM_010560
NP_001177910; NP_002175; NP_786943; NP_001351204; NP_001351205;
	NP_001351206; NP_001351207; NP_001351208; NP_002175.2; NP_001177910.1
	NP_034690
	Wikidata
View/Edit Human	View/Edit Mouse

Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a transmembrane protein which is the founding member of the class of tall cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.

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