Caspase-activated DNase

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

DNA fragmentation factor 40 kDa
DNA fragmentation factor 40 kDa
	Crystal structure of caspase-activated DNAse (CAD)
Identifiers
Symbol	DFF40
Pfam	PF09230
InterPro	IPR015311
SCOP2	1v0d / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

DFFB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IBX
Identifiers
Aliases	DFFB, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), CAD, CPAN, DFF-40, DFF2, DFF40, DNA fragmentation factor subunit beta
External IDs	OMIM: 601883 MGI: 1196287 HomoloGene: 3241 GeneCards: DFFB
Gene location (Human)
Chr.	Chromosome 1 (human)
End	3,885,429 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	154,059,583 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; endothelial cell; ; Achilles tendon; ; anterior pituitary; ; body of pancreas; ; monocyte; ; spleen; ; duodenum; ; jejunal mucosa; ; right lobe of liver;
	Top expressed in
	morula; ; thymus; ; superior frontal gyrus; ; cerebellar cortex; ; jejunum; ; Paneth cell; ; duodenum; ; primitive streak; ; spermatocyte; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme binding; nuclease activity; hydrolase activity; protein binding; deoxyribonuclease activity; protein domain specific binding; identical protein binding; disordered domain specific binding;
Cellular component	cytoplasm; cytosol; nucleolus; intracellular anatomical structure; nucleus; nucleoplasm;
Biological process	apoptotic DNA fragmentation; apoptotic chromosome condensation; apoptotic process; DNA catabolic process; protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	1677
	13368
	ENSG00000169598
	ENSMUSG00000029027
	O76075
	O54788
NM_001004285; NM_001004286; NM_001282669; NM_004402; NM_001320132;
	NM_001320136
	NM_007859
	NP_001269598; NP_001307061; NP_001307065; NP_004393
	NP_031885
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase-activated DNase (CAD) or DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene. It breaks up the DNA during apoptosis and promotes cell differentiation. It is usually an inactive monomer inhibited by ICAD. This is cleaved before dimerization.

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