Carbohydrate-binding module
In molecular biology, a carbohydrate-binding module (CBM) is a protein domain found in carbohydrate-active enzymes (for example glycoside hydrolases). The majority of these domains have carbohydrate-binding activity. Some of these domains are found on cellulosomal scaffoldin proteins. CBMs were previously known as cellulose-binding domains. CBMs are classified into numerous families, based on amino acid sequence similarity. There are currently (June 2011) 64 families of CBM in the CAZy database.
| CBM_1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
three-dimensional structures of three engineered cellulose-binding domains of cellobiohydrolase i from trichoderma reesei, nmr, 18 structures | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_1 | ||||||||
| Pfam | PF00734 | ||||||||
| InterPro | IPR000254 | ||||||||
| PROSITE | PDOC00486 | ||||||||
| SCOP2 | 1cel / SCOPe / SUPFAM | ||||||||
| CAZy | CBM1 | ||||||||
| |||||||||
| CBM_2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
solution structure of a cellulose binding domain from cellulomonas fimi by nuclear magnetic resonance spectroscopy | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_2 | ||||||||
| Pfam | PF00553 | ||||||||
| Pfam clan | CL0203 | ||||||||
| InterPro | IPR001919 | ||||||||
| PROSITE | PDOC00485 | ||||||||
| SCOP2 | 1exg / SCOPe / SUPFAM | ||||||||
| CAZy | CBM2 | ||||||||
| |||||||||
| CBM_3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of a family iiia cbd from clostridium cellulolyticum | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_3 | ||||||||
| Pfam | PF00942 | ||||||||
| Pfam clan | CL0203 | ||||||||
| InterPro | IPR001956 | ||||||||
| SCOP2 | 1nbc / SCOPe / SUPFAM | ||||||||
| CAZy | CBM3 | ||||||||
| |||||||||
| CBM_5/12 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
interactions of a family 18 chitinase with the designed inhibitor hm508, and its degradation product, chitobiono-delta-lactone | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_5_12 | ||||||||
| Pfam | PF02839 | ||||||||
| InterPro | IPR003610 | ||||||||
| SCOP2 | 1ed7 / SCOPe / SUPFAM | ||||||||
| CAZy | CBM12 | ||||||||
| |||||||||
| CBM_6 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
cbm6ct from clostridium thermocellum in complex with xylopentaose | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_6 | ||||||||
| Pfam | PF03422 | ||||||||
| Pfam clan | CL0202 | ||||||||
| InterPro | IPR005084 | ||||||||
| SCOP2 | 1gmm / SCOPe / SUPFAM | ||||||||
| CAZy | CBM6 | ||||||||
| |||||||||
| CBM_4/9 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
cbm4 structure and function | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_4_9 | ||||||||
| Pfam | PF02018 | ||||||||
| Pfam clan | CL0202 | ||||||||
| InterPro | IPR003305 | ||||||||
| SCOP2 | 1ulp / SCOPe / SUPFAM | ||||||||
| CAZy | CBM22 | ||||||||
| |||||||||
| CBM_10 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
solution structure of type x cbm | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_10 | ||||||||
| Pfam | PF02013 | ||||||||
| InterPro | IPR002883 | ||||||||
| SCOP2 | 1qld / SCOPe / SUPFAM | ||||||||
| CAZy | CBM10 | ||||||||
| |||||||||
| CBM_11 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
family 11 carbohydrate-binding module of cellulosomal cellulase lic26a-cel5e of clostridium thermocellum | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_11 | ||||||||
| Pfam | PF03425 | ||||||||
| Pfam clan | CL0202 | ||||||||
| InterPro | IPR005087 | ||||||||
| CAZy | CBM11 | ||||||||
| |||||||||
| CBM_14 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CBM_14 | ||||||||
| Pfam | PF01607 | ||||||||
| Pfam clan | CL0155 | ||||||||
| InterPro | IPR002557 | ||||||||
| SCOP2 | 1dqc / SCOPe / SUPFAM | ||||||||
| CAZy | CBM14 | ||||||||
| |||||||||
| CBM_15 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
xylan-binding module cbm15 | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_15 | ||||||||
| Pfam | PF03426 | ||||||||
| Pfam clan | CL0202 | ||||||||
| InterPro | IPR005088 | ||||||||
| SCOP2 | 1gny / SCOPe / SUPFAM | ||||||||
| CAZy | CBM15 | ||||||||
| |||||||||
| CBM_17/28 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
structure of fam17 carbohydrate binding module from clostridium cellulovorans | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_17_28 | ||||||||
| Pfam | PF03424 | ||||||||
| Pfam clan | CL0202 | ||||||||
| InterPro | IPR005086 | ||||||||
| SCOP2 | 1g0c / SCOPe / SUPFAM | ||||||||
| CAZy | CBM28 | ||||||||
| |||||||||
| Chitin_bind_1 (CBM18) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure analysis of crosslinked-wga3/glcnacbeta1,4glcnac complex | |||||||||
| Identifiers | |||||||||
| Symbol | Chitin_bind_1 | ||||||||
| Pfam | PF00187 | ||||||||
| InterPro | IPR001002 | ||||||||
| PROSITE | PDOC00025 | ||||||||
| SCOP2 | 1wgt / SCOPe / SUPFAM | ||||||||
| CAZy | CBM18 | ||||||||
| |||||||||
| CBM_19 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CBM_19 | ||||||||
| Pfam | PF03427 | ||||||||
| Pfam clan | CL0155 | ||||||||
| InterPro | IPR005089 | ||||||||
| CAZy | CBM19 | ||||||||
| |||||||||
| CBM_20 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
glucoamylase, granular starch-binding domain complex with cyclodextrin, nmr, minimized average structure | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_20 | ||||||||
| Pfam | PF00686 | ||||||||
| Pfam clan | CL0369 | ||||||||
| InterPro | IPR002044 | ||||||||
| SCOP2 | 1cdg / SCOPe / SUPFAM | ||||||||
| CAZy | CBM20 | ||||||||
| |||||||||
| CBM_21 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CBM_21 | ||||||||
| Pfam | PF03370 | ||||||||
| InterPro | IPR005036 | ||||||||
| CAZy | CBM21 | ||||||||
| |||||||||
| CBM_25 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CBM_25 | ||||||||
| Pfam | PF03423 | ||||||||
| InterPro | IPR005085 | ||||||||
| CAZy | CBM25 | ||||||||
| |||||||||
| CBM27 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
structural and thermodynamic dissection of specific mannan recognition by a carbohydrate-binding module, tmcbm27 | |||||||||
| Identifiers | |||||||||
| Symbol | CBM27 | ||||||||
| Pfam | PF09212 | ||||||||
| InterPro | IPR015295 | ||||||||
| SCOP2 | 1oh4 / SCOPe / SUPFAM | ||||||||
| |||||||||
| Chitin_bind_3 (CBM33) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of the serratia marcescens chitin-binding protein cbp21 y54a mutant. | |||||||||
| Identifiers | |||||||||
| Symbol | Chitin_bind_3 | ||||||||
| Pfam | PF03067 | ||||||||
| InterPro | IPR004302 | ||||||||
| CAZy | CBM33 | ||||||||
| |||||||||
| CBM_48 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of glycosyltrehalose trehalohydrolase from sulfolobus solfataricus | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_48 | ||||||||
| Pfam | PF02922 | ||||||||
| Pfam clan | CL0369 | ||||||||
| InterPro | IPR004193 | ||||||||
| SCOP2 | 1bf2 / SCOPe / SUPFAM | ||||||||
| CAZy | CBM48 | ||||||||
| |||||||||
| CBM49 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CBM49 | ||||||||
| Pfam | PF09478 | ||||||||
| Pfam clan | CL0203 | ||||||||
| InterPro | IPR019028 | ||||||||
| |||||||||
CBMs of microbial glycoside hydrolases play a central role in the recycling of photosynthetically fixed carbon through their binding to specific plant structural polysaccharides. CBMs can recognise both crystalline and amorphous cellulose forms. CBMs are the most common non-catalytic modules associated with enzymes active in plant cell-wall hydrolysis. Many putative CBMs have been identified by amino acid sequence alignments but only a few representatives have been shown experimentally to have a carbohydrate-binding function.
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