Calreticulin

CALR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3POW, 2CLR, 3DOW, 3POS
Identifiers
Aliases	CALR, CRT, HEL-S-99n, RO, SSA, cC1qR, calreticulin
External IDs	OMIM: 109091 MGI: 88252 HomoloGene: 37911 GeneCards: CALR
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,944,489 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,573,563 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; islet of Langerhans; ; smooth muscle tissue; ; anterior pituitary; ; rectum; ; upper lobe of left lung; ; right lobe of liver; ; ascending aorta;
	Top expressed in
	molar; ; pyloric antrum; ; spermatocyte; ; external carotid artery; ; internal carotid artery; ; epithelium of stomach; ; calvaria; ; spermatid; ; yolk sac; ; cumulus cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein folding chaperone activity; carbohydrate binding; hormone binding; metal ion binding; complement component C1q complex binding; mRNA binding; iron ion binding; unfolded protein binding; zinc ion binding; integrin binding; DNA binding; chaperone binding; peptide binding; androgen receptor binding; ubiquitin protein ligase binding; RNA binding; protein binding;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum lumen; membrane; focal adhesion; extracellular region; perinuclear region of cytoplasm; sarcoplasmic reticulum lumen; nucleus; endocytic vesicle lumen; cell surface; endoplasmic reticulum; extracellular exosome; Golgi apparatus; intracellular membrane-bounded organelle; extracellular matrix; intracellular anatomical structure; integral component of lumenal side of endoplasmic reticulum membrane; sarcoplasmic reticulum; smooth endoplasmic reticulum; MHC class I peptide loading complex; acrosomal vesicle; external side of plasma membrane; polysome; phagocytic vesicle membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; extracellular space; nuclear envelope; protein-containing complex; endoplasmic reticulum quality control compartment; collagen-containing extracellular matrix;
Biological process	negative regulation of neuron differentiation; protein folding in endoplasmic reticulum; receptor-mediated endocytosis; response to organic substance; cellular senescence; spermatogenesis; positive regulation of dendritic cell chemotaxis; regulation of apoptotic process; cellular response to organic substance; positive regulation of phagocytosis; negative regulation of intracellular steroid hormone receptor signaling pathway; regulation of transcription, DNA-templated; negative regulation of retinoic acid receptor signaling pathway; cardiac muscle cell differentiation; regulation of meiotic nuclear division; protein maturation by protein folding; positive regulation of cell cycle; protein export from nucleus; cellular response to lithium ion; peptide antigen assembly with MHC class I protein complex; antigen processing and presentation of peptide antigen via MHC class I; protein stabilization; cellular calcium ion homeostasis; negative regulation of transcription by RNA polymerase II; positive regulation of DNA replication; protein folding; negative regulation of transcription, DNA-templated; cortical actin cytoskeleton organization; chaperone-mediated protein folding; response to estradiol; response to testosterone; ATF6-mediated unfolded protein response; positive regulation of substrate adhesion-dependent cell spreading; sequestering of calcium ion; positive regulation of gene expression; positive regulation of cell population proliferation; protein localization to nucleus; glucocorticoid receptor signaling pathway; positive regulation of NIK/NF-kappaB signaling; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; negative regulation of translation; vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane; positive regulation of endothelial cell migration; negative regulation of trophoblast cell migration;
	Sources:Amigo / QuickGO
Orthologs
	811
	12317
	ENSG00000179218
	ENSMUSG00000003814
	P27797
	P14211
	NM_004343
	NM_007591
	NP_004334
	NP_031617
	Wikidata
View/Edit Human	View/Edit Mouse

Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the CALR gene.

Calreticulin is a multifunctional soluble protein that binds Ca²⁺ ions (a second messenger in signal transduction), rendering it inactive. The Ca²⁺ is bound with low affinity, but high capacity, and can be released on a signal (see inositol trisphosphate). Calreticulin is located in storage compartments associated with the endoplasmic reticulum and is considered an ER resident protein.

The term "Mobilferrin" is considered to be the same as calreticulin by some sources.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.