Calponin
Calponin is a calcium binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase, which is dependent upon calcium binding to calmodulin, releases the calponin's inhibition of the smooth muscle ATPase.
| Calponin Homology Domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
CH domain from H.Sapiends Calponin 1. PDB 1wyp | |||||||||
| Identifiers | |||||||||
| Symbol | CH | ||||||||
| Pfam | PF00307 | ||||||||
| Pfam clan | CL0188 | ||||||||
| InterPro | IPR001715 | ||||||||
| |||||||||
| calponin 1, basic, smooth muscle | |||||||
|---|---|---|---|---|---|---|---|
Solution structure of the CH domain of human Calponin 1. Rainbow colored cartoon (N-terminus = blue, C-terminus = red). | |||||||
| Identifiers | |||||||
| Symbol | CNN1 | ||||||
| NCBI gene | 1264 | ||||||
| HGNC | 2155 | ||||||
| OMIM | 600806 | ||||||
| PDB | 1WYP | ||||||
| RefSeq | NM_001299 | ||||||
| UniProt | P51911 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.2-13.1 | ||||||
| |||||||
| calponin 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CNN2 | ||||||
| NCBI gene | 1265 | ||||||
| HGNC | 2156 | ||||||
| OMIM | 602373 | ||||||
| RefSeq | NM_004368 | ||||||
| UniProt | Q99439 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.3 | ||||||
| |||||||
| calponin 3, acidic | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CNN3 | ||||||
| NCBI gene | 1266 | ||||||
| HGNC | 2157 | ||||||
| OMIM | 602374 | ||||||
| RefSeq | NM_001839 | ||||||
| UniProt | Q6FHA7 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p22-p21 | ||||||
| |||||||
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