CYP3A7

CYP3A7
Identifiers
Aliases	CYP3A7, CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, cytochrome P450 family 3 subfamily A member 7, P450HLp2
External IDs	OMIM: 605340 MGI: 88610 HomoloGene: 133564 GeneCards: CYP3A7
Gene location (Human)
Chr.	Chromosome 7 (human)
End	99,735,196 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,919,881 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; kidney tubule; ; gallbladder; ; jejunal mucosa; ; duodenum; ; metanephric glomerulus; ; corpus callosum; ; right lung; ; kidney;
	Top expressed in
	duodenum; ; jejunum; ; ileum; ; left lobe of liver; ; intestinal villus; ; epithelium of stomach; ; left colon; ; mucous cell of stomach; ; gallbladder; ; olfactory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; aromatase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; iron ion binding; oxidoreductase activity; heme binding; oxygen binding; metal ion binding; steroid hydroxylase activity; estrogen 16-alpha-hydroxylase activity; monooxygenase activity; estrogen 2-hydroxylase activity;
Cellular component	endoplasmic reticulum membrane; organelle membrane; intracellular membrane-bounded organelle; membrane; endoplasmic reticulum;
Biological process	xenobiotic metabolic process; lipid hydroxylation; steroid metabolic process; estrogen metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1551
	13113
	ENSG00000160870
	ENSMUSG00000029727
	P24462
	Q64464
	NM_000765
	NM_007819
	NP_000756
	NP_031845
	Wikidata
View/Edit Human	View/Edit Mouse

CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults. The gene location is 7q22.1.

The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.

The CYP3A7 enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The CYP3A7 gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene.

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