CYP27C1

CYP27C1
Identifiers
Aliases	CYP27C1, cytochrome P450 family 27 subfamily C member 1
External IDs	HomoloGene: 70240 GeneCards: CYP27C1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	127,220,313 bp
RNA expression pattern
	Top expressed in
	synovial membrane; ; synovial joint; ; tibia; ; palpebral conjunctiva; ; skin of abdomen; ; ganglionic eminence; ; canal of the cervix; ; vagina; ; retinal pigment epithelium; ; endometrium;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; oxidoreductase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; monooxygenase activity; retinoic acid binding; 11-cis retinal binding; all-trans retinal binding; all-trans-retinol binding; all-trans retinol 3,4-desaturase activity; all-trans retinal 3,4-desaturase activity; all-trans retinoic acid 3,4-desaturase activity; 11-cis-retinal 3,4-desaturase activity;
Cellular component	membrane; cellular component; intracellular membrane-bounded organelle;
Biological process	retinol metabolic process; retinoic acid metabolic process; retinal metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	339761
	n/a
	ENSG00000186684
	n/a
	Q4G0S4
	n/a
	NM_001001665; NM_001367501; NM_001367502
	n/a
	NP_001001665; NP_001354430; NP_001354431
	n/a
	Wikidata
View/Edit Human

CYP27C1 (cytochrome P450, family 27, subfamily C, polypeptide 1) is a protein that in humans is encoded by the CYP27C1 gene. The Enzyme Commission number (EC) for this protein is EC 1.14.19.53. The full accepted name is all-trans-retinol 3,4-desaturase and the EC number 1 classifies CYP27C1 as a oxidoreductase that acts on paired donor by reducing oxygen. It is also identifiable by the UniProt code Q4G0S4.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

The main function of the CYP27C1 enzyme is conversion of vitamin A₁ (all-trans retinol) to vitamin A₂ (all-trans 3,4-dehydroretinal).

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