CYB5R4

CYB5R4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LF5
Identifiers
Aliases	CYB5R4, NCB5OR, cb5/cb5R, dJ676J13.1, cytochrome b5 reductase 4
External IDs	OMIM: 608343 MGI: 2386848 HomoloGene: 69207 GeneCards: CYB5R4
Gene location (Human)
Chr.	Chromosome 6 (human)
End	83,967,423 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	86,959,827 bp
RNA expression pattern
	Top expressed in
	monocyte; ; sperm; ; blood; ; bone marrow; ; bone marrow cells; ; appendix; ; islet of Langerhans; ; rectum; ; Achilles tendon; ; lymph node;
	Top expressed in
	ileum; ; ganglionic eminence; ; jejunum; ; quadriceps femoris muscle; ; duodenum; ; neural tube; ; colon; ; proximal tubule; ; zone of skin; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; NAD(P)H oxidase H2O2-forming activity; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor; heme binding; metal ion binding; cytochrome-b5 reductase activity, acting on NAD(P)H;
Cellular component	perinuclear region of cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	response to antibiotic; insulin secretion; detection of oxygen; generation of precursor metabolites and energy; glucose homeostasis; superoxide metabolic process; cell development; bicarbonate transport;
	Sources:Amigo / QuickGO
Orthologs
	51167
	266690
	ENSG00000065615
	ENSMUSG00000032872
	Q7L1T6
	Q3TDX8
	NM_016230
	NM_024195; NM_001359962
	NP_057314
	NP_077157; NP_001346891
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.

NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5; MIM 250790) and CYB5 reductase (DIA1; MIM 250800).[supplied by OMIM]

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