CXCR6

CXCR6
Identifiers
Aliases	CXCR6, BONZO, CD186, STRL33, TYMSTR, C-X-C motif chemokine receptor 6
External IDs	OMIM: 605163 MGI: 1934582 HomoloGene: 38197 GeneCards: CXCR6
Gene location (Human)
Chr.	Chromosome 3 (human)
End	45,948,351 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,640,825 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; amniotic fluid; ; gallbladder; ; appendix; ; blood; ; thymus; ; rectum; ; placenta; ; palpebral conjunctiva;
	Top expressed in
	thymus; ; spleen; ; blood; ; subcutaneous adipose tissue; ; duodenum; ; right lung lobe; ; white adipose tissue; ; lip; ; carotid body; ; skin of abdomen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	C-X-C chemokine receptor activity; C-X-C chemokine binding; G protein-coupled receptor activity; chemokine receptor activity; signal transducer activity; coreceptor activity; C-C chemokine receptor activity; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; intracellular anatomical structure; external side of plasma membrane;
Biological process	viral genome replication; chemotaxis; chemokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; inflammatory response; signal transduction; immune response; positive regulation of cytosolic calcium ion concentration; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	10663
	80901
	ENSG00000172215
	ENSMUSG00000048521
	O00574
	Q9EQ16
	NM_006564
	NM_030712
	NP_006555
	NP_109637
	Wikidata
View/Edit Human	View/Edit Mouse

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene. CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor. CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.

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