Collagen, type I, alpha 1

COL1A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3GXE, 1Q7D, 2LLP, 3EJH
Identifiers
Aliases	COL1A1, EDSC, OI1, OI2, OI3, OI4, collagen type I alpha 1, collagen type I alpha 1 chain, EDSARTH1, CAFYD
External IDs	OMIM: 120150 MGI: 88467 HomoloGene: 73874 GeneCards: COL1A1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,201,632 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,843,868 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; periodontal fiber; ; gallbladder; ; tibia; ; parietal pleura; ; visceral pleura; ; spongy bone; ; pylorus; ; cardia; ; saphenous vein;
	Top expressed in
	body of femur; ; ankle; ; molar; ; belly cord; ; skin of back; ; fossa; ; ascending aorta; ; calvaria; ; aortic valve; ; corneal stroma;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; identical protein binding; platelet-derived growth factor binding; extracellular matrix structural constituent; protein binding; protease binding; extracellular matrix structural constituent conferring tensile strength;
Cellular component	endoplasmic reticulum lumen; cytoplasm; Golgi apparatus; endoplasmic reticulum; collagen; secretory granule; extracellular matrix; extracellular space; collagen type I trimer; extracellular region; collagen-containing extracellular matrix;
Biological process	cellular response to tumor necrosis factor; blood coagulation; tooth eruption; response to mechanical stimulus; response to corticosteroid; negative regulation of cell-substrate adhesion; response to steroid hormone; extracellular matrix organization; osteoblast differentiation; collagen fibril organization; skin morphogenesis; bone trabecula formation; wound healing; skin development; intramembranous ossification; positive regulation of cell migration; tooth mineralization; cellular response to epidermal growth factor stimulus; cellular response to fibroblast growth factor stimulus; response to estradiol; collagen catabolic process; response to cAMP; cellular response to vitamin E; response to fluoride; cartilage development involved in endochondral bone morphogenesis; sensory perception of sound; response to peptide hormone; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; regulation of immune response; cellular response to fluoride; positive regulation of transcription, DNA-templated; leukocyte migration; collagen biosynthetic process; protein heterotrimerization; cellular response to amino acid stimulus; endochondral ossification; response to hyperoxia; face morphogenesis; protein transport; response to nutrient; platelet activation; visual perception; positive regulation of epithelial to mesenchymal transition; response to hydrogen peroxide; embryonic skeletal system development; skeletal system morphogenesis; ossification; response to nutrient levels; positive regulation of canonical Wnt signaling pathway; protein localization to nucleus; cellular response to mechanical stimulus; skeletal system development; blood vessel development; collagen-activated tyrosine kinase receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1277
	12842
	ENSG00000108821
	ENSMUSG00000001506
	P02452
	P11087
	NM_000088
	NM_007742
	NP_000079
	NP_031768
	Wikidata
View/Edit Human	View/Edit Mouse

Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage.

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