CLEC7A

CLEC7A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BPD, 2BPE, 2BPH, 2CL8
Identifiers
Aliases	CLEC7A, BGR, CANDF4, CLECSF12, DECTIN1, CD369, SCARE2, C-type lectin domain family 7 member A, C-type lectin domain containing 7A
External IDs	OMIM: 606264 MGI: 1861431 HomoloGene: 49606 GeneCards: CLEC7A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,130,258 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	129,449,742 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; periodontal fiber; ; right lung; ; appendix; ; spleen; ; upper lobe of left lung; ; bone marrow; ; bone marrow cells; ; palpebral conjunctiva;
	Top expressed in
	right lung lobe; ; blood; ; bone marrow; ; left lung; ; mucous cell of stomach; ; subcutaneous adipose tissue; ; spleen; ; thymus; ; carotid body; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	MHC protein binding; pattern recognition receptor activity; metal ion binding; protein binding; carbohydrate binding;
Cellular component	cytoplasm; integral component of membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; nucleoplasm;
Biological process	cell recognition; immune system process; carbohydrate mediated signaling; phagocytosis, recognition; inflammatory response; T cell activation; defense response to protozoan; pattern recognition receptor signaling pathway; innate immune response; positive regulation of protein-containing complex assembly; positive regulation of interleukin-1 beta production; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of phagocytosis; positive regulation of killing of cells of other organism; positive regulation of cytokine production involved in inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	64581
	56644
	ENSG00000172243
	ENSMUSG00000079293
	Q9BXN2
	V9GXI5
NM_022570; NM_197947; NM_197948; NM_197949; NM_197950;
	NM_197951; NM_197952; NM_197953; NM_197954
	NM_020008; NM_001309637
NP_072092; NP_922938; NP_922939; NP_922940; NP_922941;
	NP_922945
	NP_001296566; NP_064392
	Wikidata
View/Edit Human	View/Edit Mouse

C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor for a variety of β-1,3-linked and β-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Expression is found on myeloid dendritic cells, monocytes, macrophages and B cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

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