CLEC4A

CLEC4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5B1W, 5B1X
Identifiers
Aliases	CLEC4A, CLECSF6, DCIR, DDB27, LLIR, CD367, HDCGC13P, C-type lectin domain family 4 member A, hDCIR
External IDs	OMIM: 605306 MGI: 1349412 HomoloGene: 49291 GeneCards: CLEC4A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	8,138,607 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	123,120,958 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; appendix; ; spleen; ; bone marrow; ; bone marrow cells; ; upper lobe of left lung; ; right lung; ; lymph node; ; gallbladder;
	Top expressed in
	spermatid; ; spleen; ; Paneth cell; ; submandibular gland; ; seminiferous tubule; ; blood; ; femur; ; body of femur; ; lip; ; carotid body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity; carbohydrate binding; calcium ion binding; mannose binding; metal ion binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	cell surface receptor signaling pathway; cell adhesion; stimulatory C-type lectin receptor signaling pathway; adaptive immune response; immune system process; innate immune response; negative regulation of cytokine production; plasmacytoid dendritic cell antigen processing and presentation; negative regulation of tumor necrosis factor production; CD8-positive, alpha-beta T cell activation; antigen processing and presentation of exogenous peptide antigen via MHC class I;
	Sources:Amigo / QuickGO
Orthologs
	50856
	26888
	ENSG00000111729
	ENSMUSG00000030148
	Q9UMR7
	Q9QZ15
	NM_016184; NM_194447; NM_194448; NM_194450
	NM_001170332; NM_001170333; NM_011999
	NP_057268; NP_919429; NP_919430; NP_919432
	NP_001163803; NP_001163804; NP_036129
	Wikidata
View/Edit Human	View/Edit Mouse

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response.

Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

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