CIITA

CIITA
Identifiers
Aliases	CIITA, C2TA, CIITAIV, MHC2TA, NLRA, class II, major histocompatibility complex, transactivator, class II major histocompatibility complex transactivator
External IDs	OMIM: 600005 MGI: 108445 HomoloGene: 207 GeneCards: CIITA
Gene location (Human)
Chr.	Chromosome 16 (human)
End	10,943,021 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	10,346,282 bp
RNA expression pattern
	Top expressed in
	monocyte; ; appendix; ; spleen; ; lymph node; ; sural nerve; ; gallbladder; ; upper lobe of left lung; ; blood; ; right lung; ; thymus;
	Top expressed in
	spleen; ; blood; ; thymus; ; subcutaneous adipose tissue; ; duodenum; ; lip; ; morula; ; jejunum; ; right ventricle; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotide binding; transcription coactivator activity; GTP binding; kinase activity; protein C-terminus binding; protein binding; acyltransferase activity; ATP binding; protein-containing complex binding;
Cellular component	PML body; nucleoplasm; nucleus;
Biological process	positive regulation of MHC class II biosynthetic process; regulation of transcription, DNA-templated; response to interferon-gamma; phosphorylation; interferon-gamma-mediated signaling pathway; response to antibiotic; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; immune response; negative regulation of transcription, DNA-templated; positive regulation of MHC class I biosynthetic process; negative regulation of collagen biosynthetic process; positive regulation of transcription by RNA polymerase II; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	4261
	12265
	ENSG00000179583
	ENSMUSG00000022504
	P33076
	P79621
NM_000246; NM_001286402; NM_001286403; NM_001379330; NM_001379331;
	NM_001379332; NM_001379333; NM_001379334
	NM_001243760; NM_001243761; NM_007575; NM_001302618; NM_001302619
NP_000237; NP_001273331; NP_001273332; NP_001366259; NP_001366260;
	NP_001366261; NP_001366262; NP_001366263
	NP_001230689; NP_001230690; NP_001289547; NP_001289548; NP_031601
	Wikidata
View/Edit Human	View/Edit Mouse

CIITA is a human gene which encodes a protein called the class II, major histocompatibility complex, transactivator. Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and cannot effectively fight infection. Chromosomal rearrangement of CIITA is involved in the pathogenesis of Hodgkin lymphoma and primary mediastinal B cell lymphoma.

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