CHRNA5

CHRNA5
Identifiers
Aliases	CHRNA5, LNCR2, cholinergic receptor nicotinic alpha 5 subunit
External IDs	OMIM: 118505 MGI: 87889 HomoloGene: 55485 GeneCards: CHRNA5
Gene location (Human)
Chr.	Chromosome 15 (human)
End	78,595,269 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	54,915,063 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; islet of Langerhans; ; secondary oocyte; ; gallbladder; ; rectum; ; stromal cell of endometrium; ; smooth muscle tissue; ; muscle of leg; ; gastrocnemius muscle; ; Achilles tendon;
	Top expressed in
	spermatid; ; substantia nigra; ; seminiferous tubule; ; morula; ; spermatocyte; ; Hindgut; ; pharynx; ; superior cervical ganglion; ; trigeminal nerve; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine receptor activity; ion channel activity; protein binding; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity; acetylcholine binding; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; acetylcholine-gated channel complex; postsynaptic membrane; membrane; plasma membrane; synapse; cell junction; dopaminergic synapse; integral component of plasma membrane; neuron projection;
Biological process	response to nicotine; synaptic transmission, cholinergic; ion transport; behavioral response to nicotine; neuromuscular synaptic transmission; signal transduction; chemical synaptic transmission; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; ion transmembrane transport; regulation of synaptic vesicle exocytosis; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	1138
	110835
	ENSG00000169684
	ENSMUSG00000035594
	P30532
	Q2MKA5
	NM_000745; NM_001307945
	NM_176844; NM_001373901; NM_001373902
	NP_000736; NP_001294874
	NP_789814; NP_001360830; NP_001360831
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-5, also known as nAChRα5, is a protein that in humans is encoded by the CHRNA5 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

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