Centrin 2

CETN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M39, 1ZMZ, 2A4J, 2GGM, 2K2I, 2OBH
Identifiers
Aliases	CETN2, CALT, CEN2, centrin 2
External IDs	OMIM: 300006 MGI: 1347085 HomoloGene: 55798 GeneCards: CETN2
Gene location (Human)
Chr.	X chromosome (human)
End	152,830,757 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	71,962,017 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; caput epididymis; ; germinal epithelium; ; corpus epididymis; ; optic nerve; ; anterior pituitary; ; seminal vesicula; ; tibia; ; hypothalamus;
	Top expressed in
	atrioventricular valve; ; endocardial cushion; ; median eminence; ; condyle; ; iris; ; fossa; ; retinal pigment epithelium; ; pineal gland; ; ciliary body; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heterotrimeric G-protein binding; metal ion binding; calcium ion binding; G-protein beta/gamma-subunit complex binding; microtubule binding; protein binding;
Cellular component	photoreceptor connecting cilium; centriole; cytoplasm; nucleoplasm; ciliary basal body; cytosol; nucleus; XPC complex; centrosome; intracellular anatomical structure; cilium; cytoskeleton; microtubule organizing center; nuclear pore nuclear basket; transcription export complex 2; nuclear envelope; nuclear pore;
Biological process	nucleotide-excision repair, DNA damage recognition; cell cycle; spermatogenesis; cell division; G2/M transition of mitotic cell cycle; regulation of cytokinesis; centriole replication; cellular response to DNA damage stimulus; global genome nucleotide-excision repair; nucleotide-excision repair, preincision complex assembly; DNA repair; nucleotide-excision repair; ciliary basal body-plasma membrane docking; mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; mitotic cytokinesis; regulation of centrosome duplication; calcium-mediated signaling; microtubule cytoskeleton organization; nucleotide-excision repair, DNA duplex unwinding; protein transport; mRNA transport;
	Sources:Amigo / QuickGO
Orthologs
	1069
	26370
	ENSG00000147400
	ENSMUSG00000031347
	P41208
	Q9R1K9
	NM_004344
	NM_019405
	NP_004335
	NP_062278
	Wikidata
View/Edit Human	View/Edit Mouse

Centrin-2 is a protein that in humans is encoded by the CETN2 gene. It belongs to the centrin family of proteins.

Centrin-2 belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that centrin-2 plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.

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