CDC6

CDC6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CCH, 2CCI, 4I5L, 4I5N
Identifiers
Aliases	CDC6, CDC18L, HsCDC18, Hscell division cycle 6, MGORS5
External IDs	OMIM: 602627 MGI: 1345150 HomoloGene: 68172 GeneCards: CDC6
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,304,657 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,814,766 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; secondary oocyte; ; rectum; ; stromal cell of endometrium; ; bone marrow cells; ; appendix; ; lymph node; ; islet of Langerhans; ; spleen; ; smooth muscle tissue;
	Top expressed in
	primitive streak; ; abdominal wall; ; morula; ; otic placode; ; endocardial cushion; ; somite; ; maxillary prominence; ; Paneth cell; ; ureter; ; hand;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; kinase binding; protein binding; ATP binding; DNA replication origin binding;
Cellular component	spindle pole; spindle midzone; nucleus; cytoplasm; nucleolus; nucleoplasm; cytosol;
Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity; cellular response to vasopressin; positive regulation of fibroblast proliferation; negative regulation of DNA replication; regulation of transcription involved in G1/S transition of mitotic cell cycle; cell division; positive regulation of cytokinesis; DNA replication checkpoint signaling; DNA replication; cellular response to angiotensin; DNA replication initiation; traversing start control point of mitotic cell cycle; positive regulation of chromosome segregation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic metaphase/anaphase transition; cell cycle; negative regulation of cell population proliferation; mitotic cell cycle; G1/S transition of mitotic cell cycle; mitotic DNA replication checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	990
	23834
	ENSG00000094804
	ENSMUSG00000017499
	Q99741
	O89033
	NM_001254
	NM_001025779; NM_011799; NM_001362735
	NP_001245
	NP_001020950; NP_035929; NP_001349664
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins.

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