CD90

THY1
Identifiers
Aliases	THY1, CD90, CDw90, Thy-1 cell surface antigen
External IDs	OMIM: 188230 MGI: 98747 HomoloGene: 4580 GeneCards: THY1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,424,985 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	43,959,876 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; stromal cell of endometrium; ; gallbladder; ; Brodmann area 9; ; orbitofrontal cortex; ; spinal ganglia; ; nucleus accumbens; ; superior frontal gyrus; ; frontal pole; ; Brodmann area 46;
	Top expressed in
	thymus; ; facial motor nucleus; ; superior frontal gyrus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; entorhinal cortex; ; motor neuron; ; pontine nuclei; ; lateral geniculate nucleus; ; superior colliculus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; enzyme binding; GPI anchor binding; GTPase activator activity; protein kinase binding; integrin binding;
Cellular component	cytosol; membrane; focal adhesion; growth cone; anchored component of plasma membrane; integral component of plasma membrane; apical plasma membrane; endoplasmic reticulum; anchored component of membrane; extracellular exosome; external side of plasma membrane; membrane raft; anchored component of external side of plasma membrane; dendrite; myelin sheath; extracellular region; plasma membrane; cell surface; axolemma; dendrite membrane; neuronal cell body membrane;
Biological process	negative regulation of T cell receptor signaling pathway; positive regulation of GTPase activity; protein autophosphorylation; negative regulation of protein kinase activity; cell adhesion; negative regulation of cell migration; angiogenesis; negative regulation of axonogenesis; cytoskeleton organization; regulation of cell migration; positive regulation of T cell activation; T cell receptor signaling pathway; retinal cone cell development; positive regulation of release of sequestered calcium ion into cytosol; C-terminal protein lipidation; regulation of cell-matrix adhesion; positive regulation of cellular extravasation; integrin-mediated signaling pathway; cell-cell signaling; positive regulation of heterotypic cell-cell adhesion; receptor clustering; positive regulation of focal adhesion assembly; negative regulation of protein tyrosine kinase activity; negative regulation of neuron projection regeneration; regulation of Rho-dependent protein serine/threonine kinase activity; focal adhesion assembly; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	7070
	21838
	ENSG00000154096
	ENSMUSG00000032011
	P04216
	P01831
	NM_006288; NM_001311160; NM_001311162; NM_001372050
	NM_009382
	NP_001298089; NP_001298091; NP_006279; NP_001358979
	NP_033408
	Wikidata
View/Edit Human	View/Edit Mouse

Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. Thy-1 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. Structural study of Thy-1 led to the foundation of the Immunoglobulin superfamily, of which it is the smallest member, and led to some of the initial biochemical description and characterization of a vertebrate GPI anchor and also the first demonstration of tissue specific differential glycosylation.

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