LILRB4

LILRB4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3P2T
Identifiers
Aliases	LILRB4, CD85K, ILT-3, ILT3, LIR-5, LIR5, leukocyte immunoglobulin like receptor B4, B4
External IDs	OMIM: 604821 MGI: 102702 HomoloGene: 86756 GeneCards: LILRB4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,670,359 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	51,362,799 bp
RNA expression pattern
	Top expressed in
	appendix; ; monocyte; ; lymph node; ; blood; ; spleen; ; gallbladder; ; placenta; ; bone marrow; ; substantia nigra; ; upper lobe of left lung;
	Top expressed in
	bone marrow; ; zone of skin; ; ovary; ; white adipose tissue; ; liver; ; uterus; ; lung; ; spleen; ; lip; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antigen binding; protein binding; signaling receptor activity;
Cellular component	extracellular exosome; plasma membrane; membrane; integral component of membrane;
Biological process	negative regulation of pri-miRNA transcription by RNA polymerase II; immune system process; adaptive immune response; signal transduction; negative regulation of osteoclast differentiation; positive regulation of regulatory T cell differentiation; negative regulation of T cell receptor signaling pathway; negative regulation of protein localization to nucleus;
	Sources:Amigo / QuickGO
Orthologs
	11006
	14727
ENSG00000275730; ENSG00000186818; ENSG00000276042; ENSG00000278279; ENSG00000278555;
	n/a
	ENSMUSG00000112023
	Q8NHJ6
	Q61450
NM_001081438; NM_001278426; NM_001278427; NM_001278428; NM_001278429;
	NM_001278430; NM_006847; NM_001394933; NM_001394934; NM_001394935; NM_001394936; NM_001394937; NM_001394938; NM_001394939
	NM_001291892; NM_001291893; NM_008147
	NP_001265355; NP_001265356; NP_001265357; NP_001265358; NP_001265359
	NP_001278821; NP_001278822; NP_032173
	Wikidata
View/Edit Human	View/Edit Mouse

Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on monocytic cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. LILRB4 has also been proposed to be a potential target for tumor immunotherapy. It has been shown to express on tumor-associated macrophages and negatively regulate immune response in tumor. The expression of LILRB4 on monocytic myeloid leukemia cells supports infiltration and inhibits T cell proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.

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