LILRA2

LILRA2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2OTP
Identifiers
Aliases	LILRA2, CD85H, ILT1, LIR-7, LIR7, leukocyte immunoglobulin like receptor A2
External IDs	OMIM: 604812 HomoloGene: 68534 GeneCards: LILRA2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,590,287 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; spleen; ; bone marrow; ; bone marrow cells; ; appendix; ; right lung; ; upper lobe of left lung; ; smooth muscle tissue; ; gallbladder;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	antigen binding; IgM binding; signaling receptor activity;
Cellular component	integral component of membrane; extracellular region; membrane; integral component of plasma membrane; plasma membrane;
Biological process	defense response; signal transduction; immune system process; innate immune response activating cell surface receptor signaling pathway; neutrophil activation involved in immune response; negative regulation of lipopolysaccharide-mediated signaling pathway; granulocyte macrophage colony-stimulating factor production; interleukin-6 production; interleukin-8 production; negative regulation of toll-like receptor 4 signaling pathway; granulocyte colony-stimulating factor production; innate immune response; positive regulation of cell activation; positive regulation of calcium ion transport;
	Sources:Amigo / QuickGO
Orthologs
	11027
	n/a
	ENSG00000239998; ENSG00000274000; ENSG00000275290; ENSG00000278634
	n/a
	Q8N149
	n/a
	NM_001130917; NM_001290270; NM_001290271; NM_006866
	n/a
	NP_001124389; NP_001277199; NP_001277200; NP_006857
	n/a
	Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM]

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