LILRB5

LILRB5
Identifiers
Aliases	LILRB5, CD85C, LIR-8, LIR8, leukocyte immunoglobulin like receptor B5
External IDs	OMIM: 604814 HomoloGene: 134027 GeneCards: LILRB5
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,257,301 bp
RNA expression pattern
	Top expressed in
	spleen; ; thymus; ; subcutaneous adipose tissue; ; left adrenal gland; ; placenta; ; duodenum; ; right coronary artery; ; gastric mucosa; ; rectum; ; transverse colon;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane;
Biological process	defense response; cell surface receptor signaling pathway; adaptive immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	10990
	n/a
ENSG00000274311; ENSG00000278437; ENSG00000273991; ENSG00000277414; ENSG00000105609;
	n/a
	n/a
	O75023
	n/a
	NM_001081442; NM_001081443; NM_001304457; NM_006840
	n/a
	NP_001074911; NP_001074912; NP_001291386; NP_006831
	n/a
	Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.

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