LILRB3

LILRB3
Identifiers
Aliases	LILRB3, CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIRB, PIR-B, leukocyte immunoglobulin like receptor B3
External IDs	OMIM: 604820 MGI: 1195974 HomoloGene: 134028 GeneCards: LILRB3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,223,506 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; spleen; ; upper lobe of left lung; ; appendix; ; right lung; ; bone marrow; ; bone marrow cells; ; right coronary artery; ; right lobe of liver;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; amyloid-beta binding; signaling receptor activity;
Cellular component	membrane; integral component of membrane; integral component of plasma membrane; plasma membrane; secretory granule membrane;
Biological process	immune system process; adaptive immune response; defense response; cell surface receptor signaling pathway; negative regulation of osteoclast differentiation; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	11025
	18729
	ENSG00000275019; ENSG00000274587; ENSG00000277816; ENSG00000204577
	n/a
	Q6PI73; O75022
	n/a
	NM_001081450; NM_006864; NM_001320960
	NM_001289428; NM_008848; NM_011093
	XP_006726238.1; XP_006726376; XP_006726377; XP_011546876; XP_011546877
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells and is believed to be a myeloid checkpoint. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

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