CD8
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.
| Putative T-cell surface glycoprotein CD8 | |
|---|---|
| Identifiers | |
| Symbol | CD8 |
| Membranome | 29 |
| CD8a molecule | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CD8A | ||||||
| Alt. symbols | CD8 | ||||||
| NCBI gene | 925 | ||||||
| HGNC | 1706 | ||||||
| OMIM | 186910 | ||||||
| RefSeq | NM_001768 | ||||||
| UniProt | P01732 | ||||||
| Other data | |||||||
| Locus | Chr. 2 p12 | ||||||
| |||||||
| CD8b molecule | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CD8B | ||||||
| Alt. symbols | CD8B1 | ||||||
| NCBI gene | 926 | ||||||
| HGNC | 1707 | ||||||
| OMIM | 186730 | ||||||
| RefSeq | NM_172099 | ||||||
| UniProt | P10966 | ||||||
| Other data | |||||||
| Locus | Chr. 2 p12 | ||||||
| |||||||
Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the MHC class I protein.
There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12.
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