CD79A

CD79A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CV9
Identifiers
Aliases	CD79A, IGA, MB-1, CD79a molecule, MB1, IGAlpha
External IDs	OMIM: 112205 MGI: 101774 HomoloGene: 31053 GeneCards: CD79A
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,881,372 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,601,622 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; appendix; ; bone marrow cells; ; blood; ; rectum; ; parotid gland; ; thymus; ; superficial temporal artery; ; thymus;
	Top expressed in
	spleen; ; bone marrow; ; thymus; ; colon; ; jejunum; ; ileum; ; lung; ; duodenum; ; morula; ; pancreas;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; protein homodimerization activity;
Cellular component	integral component of membrane; multivesicular body; membrane raft; plasma membrane; membrane; external side of plasma membrane; cytoplasm; B cell receptor complex; integral component of plasma membrane;
Biological process	B cell activation; B cell proliferation; cell surface receptor signaling pathway; adaptive immune response; immune system process; B cell differentiation; B cell receptor signaling pathway; protein homotetramerization;
	Sources:Amigo / QuickGO
Orthologs
	973
	12518
	ENSG00000105369
	ENSMUSG00000003379
	P11912
	P11911
	NM_021601; NM_001783
	NM_007655
	NP_001774; NP_067612
	NP_031681
	Wikidata
View/Edit Human	View/Edit Mouse

Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene.

The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR). This occurs in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface.

It is associated with agammaglobulinemia-3.

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