CD69

CD69
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E87, 1E8I, 1FM5, 3CCK, 3HUP
Identifiers
Aliases	CD69, AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3, CD69 molecule
External IDs	OMIM: 107273 MGI: 88343 HomoloGene: 128584 GeneCards: CD69
Gene location (Human)
Chr.	Chromosome 12 (human)
End	9,760,901 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	129,252,399 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; spleen; ; gallbladder; ; rectum; ; bone marrow cells; ; right lung; ; upper lobe of left lung; ; thymus; ; amniotic fluid;
	Top expressed in
	thymus; ; blood; ; spleen; ; secondary oocyte; ; bone marrow; ; subcutaneous adipose tissue; ; white adipose tissue; ; jejunum; ; Paneth cell; ; mammary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; transmembrane signaling receptor activity; carbohydrate binding; protein homodimerization activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; external side of plasma membrane; protein-containing complex; cell surface;
Biological process	signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	969
	12515
	ENSG00000110848
	ENSMUSG00000030156
	Q07108
	P37217
	NM_001781
	NM_001033122
	NP_001772
	NP_001028294
	Wikidata
View/Edit Human	View/Edit Mouse

CD69 (Cluster of Differentiation 69) is a human transmembrane C-Type lectin protein encoded by the CD69 gene. It is an early activation marker that is expressed in hematopoietic stem cells, T cells, and many other cell types in the immune system. It is also implicated in T cell differentiation as well as lymphocyte retention in lymphoid organs.

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