P-selectin

SELP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FSB, 1G1Q, 1G1R, 1G1S, 1HES
Identifiers
Aliases	SELP, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL, selectin P
External IDs	OMIM: 173610 MGI: 98280 HomoloGene: 2260 GeneCards: SELP
Gene location (Human)
Chr.	Chromosome 1 (human)
End	169,630,193 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	163,977,595 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; monocyte; ; left uterine tube; ; upper lobe of left lung; ; gastric mucosa; ; gallbladder; ; left coronary artery; ; canal of the cervix; ; appendix; ; subcutaneous adipose tissue;
	Top expressed in
	secondary oocyte; ; blood; ; ankle joint; ; ankle; ; bone marrow; ; Paneth cell; ; sciatic nerve; ; skin of abdomen; ; mammary gland; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; oligosaccharide binding; lipopolysaccharide binding; calcium-dependent protein binding; glycosphingolipid binding; fucose binding; carbohydrate binding; sialic acid binding; protein binding; calcium ion binding; metal ion binding;
Cellular component	integral component of membrane; membrane; platelet alpha granule membrane; platelet dense granule membrane; external side of plasma membrane; extracellular space; integral component of plasma membrane; plasma membrane;
Biological process	leukocyte cell-cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of leukocyte migration; platelet degranulation; regulation of integrin activation; cell adhesion; defense response to Gram-negative bacterium; positive regulation of phosphatidylinositol 3-kinase signaling; inflammatory response; calcium-mediated signaling using intracellular calcium source; positive regulation of platelet activation; leukocyte migration; response to lipopolysaccharide; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte tethering or rolling;
	Sources:Amigo / QuickGO
Orthologs
	6403
	20344
	ENSG00000174175
	ENSMUSG00000026580
	P16109
	Q01102
	NM_003005
	NM_011347
	NP_002996; NP_002996.2
	NP_035477
	Wikidata
View/Edit Human	View/Edit Mouse

P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.

P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets P-selectin is stored in α-granules.

Other names for P-selectin include CD62P, Granule Membrane Protein 140 (GMP-140), and Platelet Activation-Dependent Granule to External Membrane Protein (PADGEM). It was first identified in endothelial cells in 1989.

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