Decay-accelerating factor

CD55
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H03, 1H04, 1H2P, 1H2Q, 1M11, 1NWV, 1OJV, 1OJW, 1OJY, 1OK1, 1OK2, 1OK3, 1OK9, 1UOT, 1UPN, 2C8I, 2QZD, 2QZF, 2QZH, 3IYP, 3J24, 5FOA
Identifiers
Aliases	CD55, CR, CROM, DAF, TC, CD55 molecule (Cromer blood group), CHAPLE
External IDs	OMIM: 125240 MGI: 104849 HomoloGene: 479 GeneCards: CD55
Gene location (Human)
Chr.	Chromosome 1 (human)
End	207,386,804 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	130,350,746 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; palpebral conjunctiva; ; lower lobe of lung; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; blood; ; synovial joint; ; left adrenal gland; ; mucosa of urinary bladder;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; rectum; ; secondary oocyte; ; Hindgut; ; blastocyst; ; duodenum; ; peripheral nervous system; ; islet of Langerhans;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; protein binding; lipid binding;
Cellular component	membrane; Golgi membrane; plasma membrane; integral component of plasma membrane; transport vesicle; extracellular region; cell surface; membrane raft; anchored component of membrane; extracellular exosome; endoplasmic reticulum-Golgi intermediate compartment membrane; secretory granule membrane; ficolin-1-rich granule membrane;
Biological process	regulation of lipopolysaccharide-mediated signaling pathway; immune system process; positive regulation of cytosolic calcium ion concentration; positive regulation of CD4-positive, alpha-beta T cell proliferation; respiratory burst; endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of CD4-positive, alpha-beta T cell activation; CD4-positive, alpha-beta T cell cytokine production; complement activation, classical pathway; viral process; regulation of complement activation; innate immune response; viral entry into host cell; neutrophil degranulation; negative regulation of complement activation; regulation of complement-dependent cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	1604
	13137
	ENSG00000196352
	ENSMUSG00000026401
	P08174
	Q61476
NM_000574; NM_001114543; NM_001114544; NM_001114752; NM_001300902;
	NM_001300903; NM_001300904
	NM_007827; NM_001317361
	NP_000565; NP_001108224; NP_001287831; NP_001287832; NP_001287833
	NP_001304290; NP_031853; NP_001391877
	Wikidata
View/Edit Human	View/Edit Mouse

Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene.

DAF regulates the complement system on the cell surface. It recognizes C4b and C3b fragments that are created during activation of C4 (classical or lectin pathway) or C3 (alternative pathway). Interaction of DAF with cell-associated C4b of the classical and lectin pathways interferes with the conversion of C2 to C2b, thereby preventing formation of the C4b2a C3-convertase, and interaction of DAF with C3b of the alternative pathway interferes with the conversion of factor B to Bb by factor D, thereby preventing formation of the C3bBb C3 convertase of the alternative pathway. Thus, by limiting the amplification convertases of the complement cascade, DAF indirectly blocks the formation of the membrane attack complex.

This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.

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