Integrin alpha V

ITGAV
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4UM8, 4UM9
Identifiers
Aliases	ITGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V
External IDs	OMIM: 193210 MGI: 96608 HomoloGene: 20510 GeneCards: ITGAV
Gene location (Human)
Chr.	Chromosome 2 (human)
End	186,680,901 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	83,637,260 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; germinal epithelium; ; tibia; ; right ventricle; ; visceral pleura; ; glomerulus; ; metanephric glomerulus; ; parietal pleura; ; synovial joint; ; periodontal fiber;
	Top expressed in
	cumulus cell; ; retinal pigment epithelium; ; renal corpuscle; ; conjunctival fornix; ; calvaria; ; body of femur; ; external carotid artery; ; medullary collecting duct; ; internal carotid artery; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transforming growth factor beta binding; metal ion binding; voltage-gated calcium channel activity; virus receptor activity; protein kinase C binding; protease binding; extracellular matrix protein binding; extracellular matrix binding; fibronectin binding; opsonin binding; insulin-like growth factor I binding; protein binding; fibroblast growth factor binding; neuregulin binding; coreceptor activity; C-X3-C chemokine binding; signaling receptor binding; peptide binding; integrin binding;
Cellular component	lamellipodium membrane; integrin alphav-beta3 complex; extracellular exosome; alphav-beta3 integrin-IGF-1-IGF1R complex; integral component of membrane; integrin alphav-beta5 complex; membrane; integrin alphav-beta8 complex; ruffle membrane; integrin complex; microvillus membrane; filopodium membrane; external side of plasma membrane; phagocytic vesicle; plasma membrane; integral component of plasma membrane; cell surface; cytosol; focal adhesion; cell junction; specific granule membrane; integrin alphav-beta6 complex; alphav-beta3 integrin-PKCalpha complex; alphav-beta3 integrin-HMGB1 complex;
Biological process	regulation of phagocytosis; apoptotic cell clearance; endodermal cell differentiation; apolipoprotein A-I-mediated signaling pathway; negative chemotaxis; negative regulation of lipid storage; extracellular matrix organization; heterotypic cell-cell adhesion; positive regulation of cell migration; regulation of apoptotic cell clearance; substrate adhesion-dependent cell spreading; vascular endothelial growth factor receptor signaling pathway; cell-matrix adhesion; viral process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; blood vessel development; negative regulation of entry of bacterium into host cell; integrin-mediated signaling pathway; calcium ion transmembrane transport; negative regulation of macrophage derived foam cell differentiation; negative regulation of extrinsic apoptotic signaling pathway; leukocyte migration; cell-substrate adhesion; negative regulation of lipoprotein metabolic process; negative regulation of lipid transport; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of cell adhesion; ERK1 and ERK2 cascade; cell growth; positive regulation of osteoblast proliferation; cell adhesion; angiogenesis; vasculogenesis; cellular calcium ion homeostasis; positive regulation of cytosolic calcium ion concentration; positive regulation of cell population proliferation; cell migration; neutrophil degranulation; positive regulation of MAPK cascade; cell adhesion mediated by integrin; viral entry into host cell; regulation of transforming growth factor beta activation;
	Sources:Amigo / QuickGO
Orthologs
	3685
	16410
	ENSG00000138448
	ENSMUSG00000027087
	P06756
	P43406
	NM_001144999; NM_001145000; NM_002210
	NM_008402; NM_001398691
	NP_001138471; NP_001138472; NP_002201
	NP_032428; NP_001385620
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.

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