Integrin alpha 3

ITGA3
Identifiers
Aliases	ITGA3, CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, FRP-2, integrin subunit alpha 3, JEB7
External IDs	OMIM: 605025 MGI: 96602 HomoloGene: 21129 GeneCards: ITGA3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,090,481 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,967,627 bp
RNA expression pattern
	Top expressed in
	metanephric glomerulus; ; right coronary artery; ; upper lobe of left lung; ; popliteal artery; ; right lung; ; right lobe of thyroid gland; ; ascending aorta; ; left lobe of thyroid gland; ; left coronary artery; ; islet of Langerhans;
	Top expressed in
	corneal stroma; ; yolk sac; ; crypt of lieberkuhn of small intestine; ; right lung lobe; ; ileum; ; pyloric antrum; ; epithelium of stomach; ; corneal epithelium; ; duodenum; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein domain specific binding; laminin binding; collagen binding; protease binding; protein heterodimerization activity; integrin binding; fibronectin binding; protein binding;
Cellular component	extracellular exosome; synapse; integral component of membrane; cell projection; cell periphery; cell junction; growth cone; membrane; focal adhesion; cell surface; receptor complex; synaptic membrane; perinuclear region of cytoplasm; excitatory synapse; integrin complex; basolateral plasma membrane; filopodium membrane; external side of plasma membrane; integrin alpha3-beta1 complex; plasma membrane; growth cone filopodium;
Biological process	positive regulation of neuron projection development; extracellular matrix organization; lung development; mesodermal cell differentiation; skin development; maternal process involved in female pregnancy; cell-matrix adhesion; negative regulation of cell projection organization; positive regulation of cell-substrate adhesion; heart development; dendritic spine maintenance; positive regulation of gene expression; nephron development; memory; integrin-mediated signaling pathway; response to gonadotropin; leukocyte migration; renal filtration; regulation of transforming growth factor beta receptor signaling pathway; regulation of Wnt signaling pathway; regulation of BMP signaling pathway; negative regulation of Rho protein signal transduction; exploration behavior; positive regulation of epithelial cell migration; neuron migration; cell adhesion; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	3675
	16400
	ENSG00000005884
	ENSMUSG00000001507
	P26006
	Q62470
	NM_002204; NM_005501
	NM_013565; NM_001306071; NM_001306162
	NP_002195
	NP_001293000; NP_001293091; NP_038593
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.

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