CD44

CD44
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1POZ, 1UUH, 2I83, 4PZ3, 4PZ4
Identifiers
Aliases	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group)
External IDs	OMIM: 107269 MGI: 88338 HomoloGene: 508 GeneCards: CD44
Gene location (Human)
Chr.	Chromosome 11 (human)
End	35,232,402 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	102,732,010 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; stromal cell of endometrium; ; vulva; ; human penis; ; skin of abdomen; ; Achilles tendon; ; islet of Langerhans; ; superficial temporal artery; ; synovial joint; ; thymus;
	Top expressed in
	molar; ; calvaria; ; dermis; ; submandibular gland; ; parotid gland; ; body of femur; ; right lung lobe; ; hair follicle; ; skin of abdomen; ; cornea;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	collagen binding; protein binding; hyaluronic acid binding; cytokine receptor activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; Golgi apparatus; macrophage migration inhibitory factor receptor complex; membrane; focal adhesion; plasma membrane; integral component of plasma membrane; cell surface; extracellular exosome; cytosol; secretory granule membrane; apical plasma membrane; lamellipodium membrane; cell projection; microvillus; basolateral plasma membrane;
Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; monocyte aggregation; positive regulation of heterotypic cell-cell adhesion; hyaluronan catabolic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; interferon-gamma-mediated signaling pathway; extracellular matrix disassembly; extracellular matrix organization; negative regulation of apoptotic process; cellular response to fibroblast growth factor stimulus; positive regulation of peptidyl-serine phosphorylation; cartilage development; cell adhesion; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of ERK1 and ERK2 cascade; positive regulation of peptidyl-tyrosine phosphorylation; cell-matrix adhesion; positive regulation of monocyte aggregation; leukocyte migration; neutrophil degranulation; wound healing, spreading of cells; regulation of lamellipodium morphogenesis; cell-cell adhesion; inflammatory response; cell migration; T cell activation; positive regulation of kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	960
	12505
	ENSG00000026508
	ENSMUSG00000005087
	P16070
	P15379
NM_000610; NM_001001389; NM_001001390; NM_001001391; NM_001001392;
	NM_001202555; NM_001202556; NM_001202557
NM_001039150; NM_001039151; NM_001177785; NM_001177786; NM_001177787;
	NM_009851
NP_000601; NP_001001389; NP_001001390; NP_001001391; NP_001001392;
	NP_001189484; NP_001189485; NP_001189486
NP_001034239; NP_001034240; NP_001171256; NP_001171257; NP_001171258;
	NP_033981
	Wikidata
View/Edit Human	View/Edit Mouse

The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene on chromosome 11. CD44 has been referred to as HCAM (homing cell adhesion molecule), Pgp-1 (phagocytic glycoprotein-1), Hermes antigen, lymphocyte homing receptor, ECM-III, and HUTCH-1.

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