Integrin alpha 2b

ITGA2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DPK, 1DPQ, 1KUP, 1KUZ, 1M8O, 1S4W, 1TYE, 2K1A, 2K9J, 2KNC, 2MTP, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4Z7O, 4Z7Q, 5HDB, 4Z7N
Identifiers
Aliases	ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1
External IDs	OMIM: 607759 MGI: 96601 HomoloGene: 37304 GeneCards: ITGA2B
Gene location (Human)
Chr.	Chromosome 17 (human)
End	44,389,649 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	102,360,948 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spongy bone; ; pancreatic ductal cell; ; bone marrow cells; ; sperm; ; right lung; ; right lobe of thyroid gland; ; spleen; ; left lobe of thyroid gland;
	Top expressed in
	blood; ; yolk sac; ; spleen; ; lip; ; body of femur; ; bone marrow; ; proximal tubule; ; abdominal wall; ; lacrimal gland; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; fibrinogen binding; extracellular matrix binding; identical protein binding; metal ion binding;
Cellular component	focal adhesion; integrin complex; integral component of plasma membrane; platelet alpha granule membrane; integral component of membrane; membrane; external side of plasma membrane; extracellular exosome; plasma membrane; blood microparticle; cell surface;
Biological process	extracellular matrix organization; cell-matrix adhesion; positive regulation of leukocyte migration; platelet aggregation; platelet degranulation; cell adhesion; integrin-mediated signaling pathway; regulation of megakaryocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3674
	16399
	ENSG00000005961
	ENSMUSG00000034664
	P08514
	Q9QUM0
	NM_000419
	NM_010575
	NP_000410
	NP_034705
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

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