CD3G

CD3G
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SY6
Identifiers
Aliases	CD3G, CD3-GAMMA, IMD17, T3G, CD3g molecule, CD3GAMMA, CD3 gamma subunit of T-cell receptor complex
External IDs	OMIM: 186740 MGI: 88333 HomoloGene: 55 GeneCards: CD3G
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,355,161 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,891,729 bp
RNA expression pattern
	Top expressed in
	lymph node; ; thymus; ; blood; ; appendix; ; superficial temporal artery; ; bone marrow cells; ; spleen; ; rectum; ; gallbladder; ; thymus;
	Top expressed in
	thymus; ; superior surface of tongue; ; gallbladder; ; blood; ; spleen; ; ankle joint; ; subcutaneous adipose tissue; ; duodenum; ; jejunum; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor complex adaptor activity; T cell receptor binding; transmembrane signaling receptor activity; protein heterodimerization activity; protein homodimerization activity;
Cellular component	integral component of membrane; alpha-beta T cell receptor complex; integral component of plasma membrane; T cell receptor complex; membrane; clathrin-coated vesicle membrane; plasma membrane; external side of plasma membrane;
Biological process	protein transport; establishment or maintenance of cell polarity; cell surface receptor signaling pathway; T cell receptor signaling pathway; regulation of lymphocyte apoptotic process; T cell activation; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of immune response; membrane organization; protein homooligomerization; adaptive immune response; immune system process; protein-containing complex assembly; T cell differentiation; positive thymic T cell selection; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	917
	12502
	ENSG00000160654
	ENSMUSG00000002033
	P09693
	P11942
	NM_000073
	NM_009850
	NP_000064
	NP_033980
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene.

T cell antigen receptor (TCR) is associated on the T cell surface with a complex of protein called CD3. CD3G (gamma chain) is one of the four peptides (gamma, delta, epsilon and zeta) that form CD3. Defects in CD3G are associated with T cell immunodeficiency.

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