CD36

CD36
Identifiers
Aliases	CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, CD36 molecule
External IDs	OMIM: 173510 MGI: 107899 HomoloGene: 73871 GeneCards: CD36
Gene location (Human)
Chr.	Chromosome 7 (human)
End	80,679,277 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	18,093,799 bp
RNA expression pattern
	Top expressed in
	abdominal fat; ; monocyte; ; jejunal mucosa; ; right ventricle; ; subcutaneous adipose tissue; ; vena cava; ; spongy bone; ; duodenum; ; gallbladder; ; spleen;
	Top expressed in
	right lung; ; right lung lobe; ; left lung; ; left lung lobe; ; intercostal muscle; ; right ventricle; ; digastric muscle; ; atrioventricular valve; ; white adipose tissue; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; low-density lipoprotein particle receptor activity; transforming growth factor beta binding; high-density lipoprotein particle binding; lipoprotein particle binding; thrombospondin receptor activity; lipid binding; low-density lipoprotein particle binding; lipoteichoic acid immune receptor activity; amyloid-beta binding; scavenger receptor activity; Toll-like receptor binding; oxidised low-density lipoprotein particle receptor activity; protein-containing complex binding;
Cellular component	Golgi apparatus; apical plasma membrane; phagocytic vesicle; apical part of cell; brush border membrane; endocytic vesicle membrane; integral component of plasma membrane; membrane; external side of plasma membrane; integral component of membrane; platelet alpha granule membrane; membrane raft; cell surface; plasma membrane; extracellular space; specific granule membrane; intracellular anatomical structure; receptor complex;
Biological process	low-density lipoprotein particle mediated signaling; apoptotic cell clearance; positive regulation of MAPK cascade; response to lipid; nitric oxide mediated signal transduction; intestinal absorption; positive regulation of blood microparticle formation; positive regulation of blood coagulation; plasma lipoprotein particle clearance; sensory perception of taste; blood coagulation; cellular response to hydroperoxide; positive regulation of ERK1 and ERK2 cascade; receptor internalization; cellular response to bacterial lipopeptide; amyloid fibril formation; cellular response to lipopolysaccharide; cell surface receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cholesterol transport; platelet degranulation; cholesterol import; cellular response to diacyl bacterial lipopeptide; negative regulation of transcription by RNA polymerase II; transport; toll-like receptor TLR6:TLR2 signaling pathway; phagocytosis, recognition; cellular response to low-density lipoprotein particle stimulus; positive regulation of macrophage cytokine production; immune response; response to linoleic acid; negative regulation of gene expression; positive regulation of reactive oxygen species metabolic process; lipoprotein transport; positive regulation of cell-matrix adhesion; positive regulation of interleukin-12 production; triglyceride transport; long-chain fatty acid import into cell; MyD88-dependent toll-like receptor signaling pathway; response to fatty acid; regulation of removal of superoxide radicals; cellular response to lipoteichoic acid; positive regulation of cholesterol storage; intestinal cholesterol absorption; positive regulation of tumor necrosis factor production; receptor-mediated endocytosis; lipid metabolism; cGMP-mediated signaling; positive regulation of phagocytosis, engulfment; defense response to Gram-positive bacterium; positive regulation of cytosolic calcium ion concentration; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; response to stilbenoid; positive regulation of NLRP3 inflammasome complex assembly; low-density lipoprotein particle clearance; lipid storage; positive regulation of macrophage derived foam cell differentiation; cell adhesion; toll-like receptor signaling pathway; neutrophil degranulation; regulation of lipid metabolic process; production of molecular mediator involved in inflammatory response; fatty acid metabolic process; phagocytosis, engulfment; response to bacterium; positive regulation of gene expression; positive regulation of cell death; cytokine-mediated signaling pathway; regulation of lipopolysaccharide-mediated signaling pathway; regulation of toll-like receptor signaling pathway; negative regulation of protein import into nucleus; regulation of protein heterodimerization activity; positive regulation of nitric oxide biosynthetic process; positive regulation of NF-kappaB transcription factor activity; energy homeostasis; regulation of action potential; positive regulation of cold-induced thermogenesis; cellular response to oxidised low-density lipoprotein particle stimulus; oxidised low-density lipoprotein particle clearance; amyloid-beta clearance by cellular catabolic process; positive regulation of reactive oxygen species biosynthetic process; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	948
	12491
	ENSG00000135218
	ENSMUSG00000002944
	P16671
	Q08857
NM_000072; NM_001001547; NM_001001548; NM_001127443; NM_001127444;
	NM_001289908; NM_001289909; NM_001289911; NM_001371074; NM_001371075; NM_001371077; NM_001371078; NM_001371079; NM_001371080; NM_001371081
	NM_001159555; NM_001159556; NM_001159557; NM_001159558; NM_007643
NP_000063; NP_001001547; NP_001001548; NP_001120915; NP_001120916;
	NP_001276837; NP_001276838; NP_001276840; NP_001358003; NP_001358004; NP_001358006; NP_001358007; NP_001358008; NP_001358009; NP_001358010
	NP_001153027; NP_001153028; NP_001153029; NP_001153030; NP_031669
	Wikidata
View/Edit Human	View/Edit Mouse

CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral membrane protein found on the surface of many cell types in vertebrate animals. It imports fatty acids inside cells and is a member of the class B scavenger receptor family of cell surface proteins. CD36 binds many ligands including collagen, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, oxidized low density lipoprotein, native lipoproteins, oxidized phospholipids, and long-chain fatty acids.

Work in genetically modified rodents suggest a role for CD36 in fatty acid metabolism, heart disease, taste, and dietary fat processing in the intestine. It may be involved in glucose intolerance, atherosclerosis, arterial hypertension, diabetes, cardiomyopathy, Alzheimer's disease and various cancers, mostly of epithelial origin (breast, prostate, ovary, and colon) and also for hepatic carcinoma and gliomas.

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