Neuropilin 1

NRP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KEX, 2QQI, 2QQM, 2QQN, 3I97, 4DEQ, 4RN5, 5C7G
Identifiers
Aliases	NRP1, BDCA4, CD304, NP1, NRP, VEGF165R, Neuropilin 1
External IDs	OMIM: 602069 MGI: 106206 HomoloGene: 2876 GeneCards: NRP1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	33,336,262 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	129,229,844 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; pericardium; ; Achilles tendon; ; synovial joint; ; right ventricle; ; gallbladder; ; left ventricle; ; subcutaneous adipose tissue; ; smooth muscle tissue; ; superficial temporal artery;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; left lung; ; renal corpuscle; ; trigeminal ganglion; ; superior cervical ganglion; ; left lung lobe; ; carotid body; ; brown adipose tissue; ; right lung;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	heparin binding; vascular endothelial growth factor binding; cytokine binding; semaphorin receptor activity; coreceptor activity; metal ion binding; vascular endothelial growth factor-activated receptor activity; growth factor binding; protein binding; GTPase activator activity; protein kinase binding;
Cellular component	cytosol; membrane; extracellular region; semaphorin receptor complex; cell surface; sorting endosome; integral component of membrane; growth cone; receptor complex; plasma membrane; axon; neuronal cell body; early endosome; neurofilament; cytoplasmic vesicle; extracellular space; focal adhesion; neuron projection; glutamatergic synapse; integral component of postsynaptic membrane;
Biological process	negative regulation of neuron apoptotic process; facioacoustic ganglion development; vascular endothelial growth factor signaling pathway; VEGF-activated neuropilin signaling pathway involved in axon guidance; toxin transport; cell migration involved in sprouting angiogenesis; semaphorin-plexin signaling pathway involved in axon guidance; positive regulation of retinal ganglion cell axon guidance; positive regulation of smooth muscle cell migration; sympathetic neuron projection guidance; vascular endothelial growth factor receptor signaling pathway; sensory neuron axon guidance; angiogenesis; positive regulation of ERK1 and ERK2 cascade; animal organ morphogenesis; protein localization to early endosome; trigeminal nerve structural organization; regulation of axon extension involved in axon guidance; coronary artery morphogenesis; negative regulation of extrinsic apoptotic signaling pathway; neuron development; trigeminal nerve morphogenesis; angiogenesis involved in coronary vascular morphogenesis; commissural neuron axon guidance; negative regulation of axon extension involved in axon guidance; heart development; response to wounding; artery morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; branching involved in blood vessel morphogenesis; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; facial nerve structural organization; hepatocyte growth factor receptor signaling pathway; axonal fasciculation; retina vasculature morphogenesis in camera-type eye; dorsal root ganglion morphogenesis; axon extension involved in axon guidance; sympathetic ganglion development; cell differentiation; semaphorin-plexin signaling pathway involved in neuron projection guidance; cellular response to hepatocyte growth factor stimulus; dendrite development; sprouting angiogenesis; neuron migration; nervous system development; regulation of retinal ganglion cell axon guidance; branchiomotor neuron axon guidance; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; negative regulation of axon extension; retinal ganglion cell axon guidance; renal artery morphogenesis; ventral trunk neural crest cell migration; positive regulation of endothelial cell proliferation; sympathetic nervous system development; endothelial tip cell fate specification; cell-cell signaling; regulation of vesicle-mediated transport; trigeminal ganglion development; positive regulation of cytokine activity; positive regulation of axon extension involved in axon guidance; axon guidance; vestibulocochlear nerve structural organization; multicellular organism development; neural crest cell migration involved in autonomic nervous system development; endothelial cell chemotaxis; axonogenesis involved in innervation; dichotomous subdivision of terminal units involved in salivary gland branching; cellular response to vascular endothelial growth factor stimulus; motor neuron axon guidance; nerve development; cell migration; sympathetic neuron projection extension; semaphorin-plexin signaling pathway; signal transduction; otic placode development; motor neuron migration; outflow tract septum morphogenesis; substrate-dependent cell migration, cell extension; integrin-mediated signaling pathway; positive regulation of endothelial cell migration; actin cytoskeleton reorganization; regulation of Cdc42 protein signal transduction; substrate adhesion-dependent cell spreading; neuropilin signaling pathway; VEGF-activated neuropilin signaling pathway; positive regulation of phosphorylation; endothelial cell migration; positive regulation of GTPase activity; positive regulation of angiogenesis; positive regulation of filopodium assembly; positive regulation of stress fiber assembly; positive regulation of focal adhesion assembly; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of actin cytoskeleton reorganization; postsynapse organization; basal dendrite development; basal dendrite arborization;
	Sources:Amigo / QuickGO
Orthologs
	8829
	18186
	ENSG00000099250
	ENSMUSG00000025810
	O14786
	P97333
NM_001024628; NM_001024629; NM_001244972; NM_001244973; NM_003873;
	NM_001330068
	NM_008737; NM_001358959; NM_001358960
NP_001019799; NP_001019800; NP_001231901; NP_001231902; NP_001316997;
	NP_003864
	NP_032763; NP_001345888; NP_001345889
	Wikidata
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Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins.

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