ATP1B3

ATP1B3
Identifiers
Aliases	ATP1B3, ATPB-3, CD298, ATPase Na+/K+ transporting subunit beta 3
External IDs	OMIM: 601867 MGI: 107788 HomoloGene: 37510 GeneCards: ATP1B3
Gene location (Human)
Chr.	Chromosome 3 (human)
End	141,926,549 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	96,246,495 bp
RNA expression pattern
	Top expressed in
	sperm; ; stromal cell of endometrium; ; vulva; ; human penis; ; skin of abdomen; ; olfactory bulb; ; renal medulla; ; hair follicle; ; trigeminal ganglion; ; nipple;
	Top expressed in
	sciatic nerve; ; seminiferous tubule; ; corneal stroma; ; molar; ; utricle; ; superior surface of tongue; ; optic nerve; ; cervix; ; ciliary body; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATPase binding; P-type sodium:potassium-exchanging transporter activity; ATPase activator activity;
Cellular component	cytoplasm; integral component of membrane; membrane; melanosome; plasma membrane; sodium:potassium-exchanging ATPase complex; caveola; extracellular exosome;
Biological process	regulation of cardiac conduction; positive regulation of ATP-dependent activity; positive regulation of sodium ion export across plasma membrane; sodium ion transport; cellular sodium ion homeostasis; sodium ion export across plasma membrane; metal ion transport; positive regulation of potassium ion import across plasma membrane; protein stabilization; ion transport; cellular potassium ion homeostasis; potassium ion transport; membrane repolarization; ion transmembrane transport; protein localization to plasma membrane; leukocyte migration; positive regulation of potassium ion transmembrane transporter activity; establishment or maintenance of transmembrane electrochemical gradient; transport; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	483
	11933
	ENSG00000069849
	ENSMUSG00000032412
	P54709
	P97370
	NM_001679
	NM_007502; NM_001357212; NM_001357213
	NP_001670
	NP_031528; NP_001344141; NP_001344142
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. ATP1B3 has also been designated as CD298 (cluster of differentiation 298).

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.

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