CD248

CD248
Identifiers
Aliases	CD248, CD164L1, TEM1, CD248 molecule
External IDs	OMIM: 606064 MGI: 1917695 HomoloGene: 10699 GeneCards: CD248
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,317,044 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,120,710 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; subcutaneous adipose tissue; ; gastric mucosa; ; synovial joint; ; pericardium; ; canal of the cervix; ; left uterine tube; ; nipple; ; saphenous vein; ; vena cava;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; molar; ; lip; ; occiput; ; occipital bone; ; ankle; ; sciatic nerve; ; dermis; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; extracellular matrix binding; carbohydrate binding; molecular function; extracellular matrix protein binding;
Cellular component	cytoplasm; integral component of membrane; extracellular exosome; membrane; extracellular matrix; external side of plasma membrane;
Biological process	positive regulation of endothelial cell apoptotic process; lymph node development; cell migration; positive regulation of cell population proliferation; anatomical structure regression; biological process;
	Sources:Amigo / QuickGO
Orthologs
	57124
	70445
	ENSG00000174807
	ENSMUSG00000056481
	Q9HCU0
	Q91V98
	NM_020404
	NM_054042
	NP_065137
	NP_473383
	Wikidata
View/Edit Human	View/Edit Mouse

Endosialin is a protein that in humans is encoded by the CD248 gene.

Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise three other members, CLEC14A, CD93 and Thrombomodulin the latter of which are better characterized.

The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo and uterus and in tumor development and growth.

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