T-cell surface glycoprotein CD3 zeta chain

CD247
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TCE, 1YGR, 2HAC, 2OQ1, 3IK5, 3IOZ, 4XZ1
Identifiers
Aliases	CD247, CD3-ZETA, CD3H, CD3Q, CD3Z, IMD25, T3Z, TCRZ, CD247 molecule, CD3zeta
External IDs	OMIM: 186780 MGI: 88334 HomoloGene: 12818 GeneCards: CD247
Gene location (Human)
Chr.	Chromosome 1 (human)
End	167,518,610 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	165,704,846 bp
RNA expression pattern
	Top expressed in
	thymus; ; blood; ; lymph node; ; spleen; ; appendix; ; bone marrow; ; bone marrow cells; ; upper lobe of left lung; ; jejunal mucosa; ; right lung;
	Top expressed in
	thymus; ; blood; ; aortic valve; ; ascending aorta; ; spleen; ; subcutaneous adipose tissue; ; spermatid; ; supraoptic nucleus; ; morula; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; identical protein binding; protein homodimerization activity; protein tyrosine kinase binding;
Cellular component	cytoplasm; integral component of membrane; alpha-beta T cell receptor complex; plasma membrane; T cell receptor complex; membrane;
Biological process	cell surface receptor signaling pathway; mitigation of host defenses by virus; T cell receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of immune response; viral process; protein homotetramerization; protein homotrimerization; adaptive immune response; immune system process; interleukin-2 production; positive regulation of protein localization to cell surface;
	Sources:Amigo / QuickGO
Orthologs
	919
	12503
	ENSG00000198821
	ENSMUSG00000005763
	P20963
	Q3UU54; P24161
	NM_000734; NM_198053; NM_001378515; NM_001378516
	NM_001113391; NM_001113392; NM_001113393; NM_001113394; NM_031162
	NP_000725; NP_932170; NP_001365444; NP_001365445
NP_112439.1; NP_001106862.1; NP_001106862; NP_001106863; NP_001106864;
	NP_112439
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.

Some older literature mention a similar protein called "CD3 eta" in mice. It is now understood to be an isoform differing in the last exon.

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