LAMP3

LAMP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AKM
Identifiers
Aliases	LAMP3, CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403, lysosomal-associated membrane protein 3, lysosomal associated membrane protein 3
External IDs	OMIM: 605883 MGI: 2441659 HomoloGene: 8670 GeneCards: LAMP3
Gene location (Human)
Chr.	Chromosome 3 (human)
End	183,163,839 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	19,525,125 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; sperm; ; visceral pleura; ; palpebral conjunctiva; ; upper lobe of lung; ; appendix; ; upper lobe of left lung; ; hair follicle; ; bronchial epithelial cell; ; thymus;
	Top expressed in
	lung; ; blastocyst; ; lens; ; spleen; ; spermatid; ; heart;
	More reference expression data
	More reference expression data
Orthologs
	27074
	239739
	ENSG00000078081
	ENSMUSG00000041247
	Q9UQV4
	Q7TST5
	NM_014398
	NM_177356
	NP_055213
	NP_796330
	Wikidata
View/Edit Human	View/Edit Mouse

Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene. It is one of the lysosome-associated membrane glycoproteins.

LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along with LAMP1 and LAMP2, these proteins make up the members of the glycoconjugate coat present on the inside of the lysosomal membrane. In humans, this protein is almost exclusively found in mature Dendritic cells. While LAMP3 can be observed on the surface of dendritic cells, the protein is mainly found within lysosomes. LAMP3 first appears in the MHC Class II compartment and in cells aids in the identifying and processing of an antigen during an immune response. LAMP3 protein is linked with the maturation of dendritic cells, and as a marker for transformed type II pneumocytes or alveolar cells.

Studies have linked LAMP3 with the inhibition of the viral replication of Influenza A cells.

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