TEK tyrosine kinase

TEK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4K0V, 1FVR, 2GY5, 2GY7, 2OO8, 2OSC, 2P4I, 2WQB, 3L8P, 4X3J
Identifiers
Aliases	TEK, CD202B, TIE-2, TIE2, VMCM, VMCM1, TEK tyrosine kinase, TEK receptor tyrosine kinase, GLC3E
External IDs	OMIM: 600221 MGI: 98664 HomoloGene: 397 GeneCards: TEK
Gene location (Human)
Chr.	Chromosome 9 (human)
End	27,230,174 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	94,763,213 bp
RNA expression pattern
	Top expressed in
	right lung; ; visceral pleura; ; upper lobe of left lung; ; oocyte; ; parietal pleura; ; secondary oocyte; ; lower lobe of lung; ; subcutaneous adipose tissue; ; metanephric glomerulus; ; placenta;
	Top expressed in
	right lung; ; right lung lobe; ; left lung; ; atrium; ; left lung lobe; ; atrioventricular valve; ; semi-lunar valve; ; aortic valve; ; endocardial cushion; ; ascending aorta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; signaling receptor activity; growth factor binding; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; cell-cell junction; focal adhesion; integral component of plasma membrane; stress fiber; extracellular region; microvillus; cell surface; basal plasma membrane; cell junction; basolateral plasma membrane; apical plasma membrane; actin filament; membrane raft; cytoskeleton; microtubule organizing center; plasma membrane; receptor complex;
Biological process	negative regulation of endothelial cell apoptotic process; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; response to hypoxia; positive regulation of endothelial cell proliferation; heart trabecula formation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of endothelial cell apoptotic process; cell-cell signaling; response to peptide hormone; sprouting angiogenesis; negative regulation of apoptotic process; endochondral ossification; positive regulation of intracellular signal transduction; response to organic substance; positive regulation of angiogenesis; MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of endothelial cell migration; response to estrogen; heart development; regulation of vascular permeability; protein phosphorylation; protein complex oligomerization; endothelial cell proliferation; angiogenesis; Tie signaling pathway; positive regulation of ERK1 and ERK2 cascade; negative regulation of angiogenesis; protein autophosphorylation; positive regulation of focal adhesion assembly; regulation of establishment or maintenance of cell polarity; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; substrate adhesion-dependent cell spreading; response to cAMP; definitive hemopoiesis; positive regulation of actin cytoskeleton reorganization; negative regulation of inflammatory response; leukocyte migration; signal transduction; glomerulus vasculature development; negative regulation of signal transduction; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	7010
	21687
	ENSG00000120156
	ENSMUSG00000006386
	Q02763
	Q02858
	NM_000459; NM_001290077; NM_001290078; NM_001375475; NM_001375476
	NM_001290549; NM_001290551; NM_013690
	NP_000450; NP_001277006; NP_001277007; NP_001362404; NP_001362405
	NP_001277478; NP_001277480; NP_038718
	Wikidata
View/Edit Human	View/Edit Mouse

Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor.

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