CD1b

CD1B
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1GZP, 1GZQ, 1UQS, 2H26, 3OV6, 3T8X, 4ONO
Identifiers
Aliases	CD1B, CD1, CD1A, R1, CD1b molecule
External IDs	OMIM: 188360 HomoloGene: 129921 GeneCards: CD1B
Gene location (Human)
Chr.	Chromosome 1 (human)
End	158,331,531 bp
RNA expression pattern
	Top expressed in
	thymus; ; monocyte; ; lymph node; ; cecum; ; appendix; ; vulva; ; rectum; ; gallbladder; ; pharynx; ; muscle tissue;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	beta-2-microglobulin binding; endogenous lipid antigen binding; lipopeptide binding; protein binding; exogenous lipid antigen binding;
Cellular component	integral component of membrane; cell surface; lysosomal membrane; endosome; lysosome; endosome membrane; membrane; plasma membrane; extracellular space; external side of plasma membrane;
Biological process	antigen processing and presentation, exogenous lipid antigen via MHC class Ib; adaptive immune response; immune system process; regulation of immune response; positive regulation of T cell mediated cytotoxicity; immune response; antigen processing and presentation, endogenous lipid antigen via MHC class Ib;
	Sources:Amigo / QuickGO
Orthologs
	910
	n/a
	ENSG00000158485
	n/a
	P29016
	n/a
	NM_001764
	n/a
	NP_001755
	n/a
	Wikidata
View/Edit Human

T-cell surface glycoprotein CD1b is a protein that in humans is encoded by the CD1B gene.

CD1b belongs to group 1 of CD1 family of transmembrane glycoproteins. CD1 molecules are expressed on the surface of numerous different human antigen presenting cells (DCs, monocytes and some thymocytes). This specialised group of glycoproteins present self and non-self lipid-based antigens to specific αβ T-cells. CD1 molecules are structurally related to the major histocompatibility complex (MHC), belonging to MHC class I-like genes. The human CD1 locus is found on chromosome 1 and contains five nonpolymorphic genes (CD1a, CD1b, CD1c, CD1d and CD1e).

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