CD180

CD180
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B2D
Identifiers
Aliases	CD180, LY64, Ly78, RP105, CD180 molecule
External IDs	OMIM: 602226 MGI: 1194924 HomoloGene: 4077 GeneCards: CD180
Gene location (Human)
Chr.	Chromosome 5 (human)
End	67,196,799 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	102,876,137 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; lymph node; ; monocyte; ; spleen; ; appendix; ; bone marrow cells; ; blood; ; superficial temporal artery; ; spongy bone; ; thymus;
	Top expressed in
	secondary oocyte; ; spleen; ; right ventricle; ; blood; ; thymus; ; lip; ; bone marrow; ; tracheobronchial tree; ; trachea; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; extracellular space; extracellular matrix;
Biological process	positive regulation of lipopolysaccharide-mediated signaling pathway; innate immune response; cellular response to lipopolysaccharide; B cell proliferation involved in immune response; immune system process; toll-like receptor signaling pathway; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	4064
	17079
	ENSG00000134061
	ENSMUSG00000021624
	Q99467
	Q62192
	NM_005582
	NM_008533; NM_001360519
	NP_005573
	NP_032559; NP_001347448
	Wikidata
View/Edit Human	View/Edit Mouse

CD180 antigen is a protein that in humans is encoded by the CD180 gene.

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.

Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia.

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