Fas ligand

FASLG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MSV
Identifiers
Aliases	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand
External IDs	OMIM: 134638 MGI: 99255 HomoloGene: 533 GeneCards: FASLG
Gene location (Human)
Chr.	Chromosome 1 (human)
End	172,666,876 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	161,616,064 bp
RNA expression pattern
	Top expressed in
	blood; ; lymph node; ; spleen; ; jejunal mucosa; ; gallbladder; ; duodenum; ; rectum; ; bone marrow; ; appendix; ; right lobe of liver;
	Top expressed in
	blood; ; spermatid; ; placenta; ; spleen; ; duodenum; ; jejunum; ; thymus; ; upper arm; ; triceps brachii muscle; ; bone marrow;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; protein binding; tumor necrosis factor receptor binding; signaling receptor binding; death receptor binding;
Cellular component	integral component of membrane; membrane; cytoplasmic vesicle lumen; plasma membrane; integral component of plasma membrane; cell surface; lysosomal lumen; caveola; perinuclear region of cytoplasm; membrane raft; lysosome; extracellular exosome; cytoplasmic vesicle; nucleus; external side of plasma membrane; extracellular region; extracellular space;
Biological process	T cell apoptotic process; regulation of transcription, DNA-templated; cell-cell signaling; endosomal lumen acidification; negative regulation of transcription by RNA polymerase II; retinal cell programmed cell death; transcription, DNA-templated; response to lipopolysaccharide; positive regulation of neuron apoptotic process; positive regulation of endothelial cell apoptotic process; necroptotic signaling pathway; immune response; positive regulation of cell population proliferation; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of angiogenesis; regulation of extrinsic apoptotic signaling pathway via death domain receptors; cellular chloride ion homeostasis; response to growth factor; inflammatory cell apoptotic process; positive regulation of epidermal growth factor receptor signaling pathway; extrinsic apoptotic signaling pathway via death domain receptors; signal transduction; extrinsic apoptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; necroptosis; apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; apoptotic process; release of sequestered calcium ion into cytosol by endoplasmic reticulum; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	356
	14103
	ENSG00000117560
	ENSMUSG00000000817
	P48023
	P41047
	NM_001302746; NM_000639
	NM_001205243; NM_010177
	NP_000630; NP_001289675
	NP_001192172; NP_034307
	Wikidata
View/Edit Human	View/Edit Mouse

Fas ligand (FasL or CD95L or CD178) is a type-II transmembrane protein expressed on cytotoxic T lymphocytes and natural killer (NK) cells. Its binding with Fas receptor (FasR) induces programmed cell death in the FasR-carrying target cell. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.

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