SIRPG

SIRPG
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2JJW, 4I2X
Identifiers
Aliases	SIRPG, CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma
External IDs	OMIM: 605466 HomoloGene: 56809 GeneCards: SIRPG
Gene location (Human)
Chr.	Chromosome 20 (human)
End	1,657,779 bp
RNA expression pattern
	Top expressed in
	lymph node; ; blood; ; appendix; ; spleen; ; thymus; ; rectum; ; bone marrow cells; ; gallbladder; ; pharynx; ; thymus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; intracellular anatomical structure;
Biological process	cell-cell signaling; cell adhesion; intracellular signal transduction; positive regulation of T cell activation; leukocyte migration; positive regulation of cell population proliferation; negative regulation of cell population proliferation; positive regulation of cell-cell adhesion; positive regulation of phagocytosis;
	Sources:Amigo / QuickGO
Orthologs
	55423
	n/a
	ENSG00000089012
	n/a
	Q9P1W8
	n/a
	NM_001039508; NM_018556; NM_080816
	n/a
	NP_001034597; NP_061026; NP_543006
	n/a
	Wikidata
View/Edit Human

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene. SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.

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