CD16
CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells. CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily (IgSF) involved in antibody-dependent cellular cytotoxicity (ADCC). It can be used to isolate populations of specific immune cells through fluorescent-activated cell sorting (FACS) or magnetic-activated cell sorting, using antibodies directed towards CD16.
| Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FCGR3A | ||||||
| Alt. symbols | FCGR3, FCG3 | ||||||
| NCBI gene | 2214 | ||||||
| HGNC | 3619 | ||||||
| OMIM | 146740 | ||||||
| RefSeq | NM_000569 | ||||||
| UniProt | P08637 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q23 | ||||||
| |||||||
| Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FCGR3B | ||||||
| Alt. symbols | FCGR3, FCG3 | ||||||
| NCBI gene | 2215 | ||||||
| HGNC | 3620 | ||||||
| OMIM | 610665 | ||||||
| RefSeq | NM_000570 | ||||||
| UniProt | O75015 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q23 | ||||||
| |||||||
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