VE-cadherin

CDH5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KOH
Identifiers
Aliases	CDH5, 7B4, CD144, VE-cadherin, cadherin 5
External IDs	OMIM: 601120 MGI: 105057 HomoloGene: 1359 GeneCards: CDH5
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,404,784 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	104,871,143 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; lower lobe of lung; ; subcutaneous adipose tissue; ; placenta; ; pericardium; ; vena cava; ; left ventricle; ; right lobe of thyroid gland; ; left lobe of thyroid gland;
	Top expressed in
	left lung; ; interventricular septum; ; left lung lobe; ; right lung; ; right lung lobe; ; extensor digitorum longus muscle; ; plantaris muscle; ; extraocular muscle; ; ankle joint; ; thoracic diaphragm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; beta-catenin binding; transmembrane transporter binding; metal ion binding; protein binding; protein phosphatase binding; signaling receptor binding; cytoskeletal protein binding; protein homodimerization activity; cadherin binding; vascular endothelial growth factor receptor 2 binding;
Cellular component	integral component of membrane; membrane; cell-cell junction; bicellular tight junction; adherens junction; cell surface; cell junction; external side of plasma membrane; cell periphery; plasma membrane; catenin complex;
Biological process	positive regulation of establishment of endothelial barrier; cell adhesion; cell-cell junction assembly; adherens junction organization; transforming growth factor beta receptor signaling pathway; regulation of establishment of cell polarity; negative regulation of cell population proliferation; homophilic cell adhesion via plasma membrane adhesion molecules; blood vessel maturation; cell-cell adhesion; negative regulation of inflammatory response; positive regulation of angiogenesis; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1003
	12562
	ENSG00000179776
	ENSMUSG00000031871
	P33151
	P55284
	NM_001114117; NM_001795
	NM_009868
	NP_001786
	NP_033998
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-5, or VE-cadherin (vascular endothelial cadherin), also known as CD144 (Cluster of Differentiation 144), is a type of cadherin. It is encoded by the human gene CDH5.

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