CD14

CD14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GLP
Identifiers
Aliases	CD14, entrez:929, CD14 molecule
External IDs	OMIM: 158120 MGI: 88318 HomoloGene: 493 GeneCards: CD14
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,633,700 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,859,851 bp
RNA expression pattern
	Top expressed in
	monocyte; ; right lobe of liver; ; right coronary artery; ; blood; ; left adrenal gland; ; right adrenal gland; ; synovial joint; ; gallbladder; ; synovial membrane; ; upper lobe of left lung;
	Top expressed in
	ankle joint; ; cervix; ; right lung lobe; ; left colon; ; submandibular gland; ; trachea; ; carotid body; ; corneal stroma; ; right ventricle; ; calvaria;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lipopolysaccharide binding; opsonin receptor activity; lipoteichoic acid binding; protein binding; peptidoglycan immune receptor activity; lipopeptide binding;
Cellular component	Golgi apparatus; membrane; plasma membrane; extracellular region; cell surface; lipopolysaccharide receptor complex; anchored component of external side of plasma membrane; membrane raft; anchored component of membrane; endosome membrane; extracellular exosome; external side of plasma membrane; extracellular space; secretory granule membrane;
Biological process	toll-like receptor TLR1:TLR2 signaling pathway; response to bacterium; toll-like receptor 4 signaling pathway; immune system process; cellular response to diacyl bacterial lipopeptide; positive regulation of interferon-gamma production; response to magnesium ion; response to heat; response to electrical stimulus; MyD88-dependent toll-like receptor signaling pathway; receptor-mediated endocytosis; cellular response to triacyl bacterial lipopeptide; TRIF-dependent toll-like receptor signaling pathway; response to tumor necrosis factor; positive regulation of endocytosis; cell surface receptor signaling pathway; response to lipopolysaccharide; cellular response to lipoteichoic acid; phagocytosis; positive regulation of tumor necrosis factor production; inflammatory response; response to ethanol; I-kappaB kinase/NF-kappaB signaling; toll-like receptor TLR6:TLR2 signaling pathway; cellular response to lipopolysaccharide; response to molecule of bacterial origin; positive regulation of type I interferon production; lipopolysaccharide-mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; apoptotic process; innate immune response; necroptosis; negative regulation of MyD88-independent toll-like receptor signaling pathway; apoptotic signaling pathway; toll-like receptor signaling pathway; neutrophil degranulation; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	929
	12475
	ENSG00000170458
	ENSMUSG00000051439
	P08571
	P10810
	NM_001174105; NM_000591; NM_001040021; NM_001174104
	NM_009841
	NP_000582; NP_001035110; NP_001167575; NP_001167576
	NP_033971
	Wikidata
View/Edit Human	View/Edit Mouse

CD14 (cluster of differentiation 14) is a human protein made mostly by macrophages as part of the innate immune system. It helps to detect bacteria in the body by binding lipopolysaccharide (LPS), a pathogen-associated molecular pattern (PAMP).

CD14 exists in two forms, one anchored to the membrane by a glycosylphosphatidylinositol (GPI) tail (mCD14), the other a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa).

The x-ray crystal structure of human CD14 reveals a monomeric, bent solenoid structure containing a hydrophobic amino-terminal pocket.

CD14 was the first described pattern recognition receptor.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.